Die physikalischen Daten stimmen mit den in der Literatur''angegebenen iiberein. Die Aufarbeitung analog 2 ergibt 2.Bestrahlung von N-Diisobutylaminomethyl-phthalimid 2,O g N-(Diisobutylamino-methyl)-phthalimid werden in 200 ml Methanol 4 Std. bestrahlt. Der Ansatz wird eingeengt, mit 10 ml Wasser ausgekocht und der Ruckstand rnit wenig Methanol versetzt. Es kristallisieren 0,6 g Bis-phthalimidomethyl-isobutylamin (4) aus. Die physikalischen Daten stimmen mit den in der Literatnr')angegebenen uberein. Die Aufubeitung analog 2 ergibt 2.
Während (Ia) bei der Photolyse in THF die Produkte (IIa), (IIIa) und (IVa) ergibt, wird aus (Ib) das Derivat (IIIb) erhalten, (IIIb) reagiert in der Hitze oder in Anwesenheit von HBr zu (V).
Modern medical science has focused attention on the chemistry of living cells. This report describes methods for recovering from yeast, compounds essential to all living tissue. Nucleic acid is readily extracted from yeast in yields of 6% on a dry basis. From it, nucleotides and nucleosides are prepared by hydrolysis. Yeast enzyme systems are used to convert nucleosides to phosphorylated esters, and to prepare sugar phosphates. This organism is also a good source for glutathione and cozymase. The yeast derivatives described are being used in research on fundamental biochemical mechanisms. Prepared in radioactive form by biosynthesis, they are powerful investigative tools. Adenosine nucleotides, glutathione, and nucleic acid, among others, are being studied as possible therapeutic agents in metabolic diseases. Economical recovery methods from available raw materials for these hitherto rare chemicals are of considerable potential value.
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