HighlightsThis is the first reported human case of bacteremia caused by Streptococcus canis having scm gene encoding M-like protein.The identity was based on similarity of its 16S rRNA and detection of the specific cfg gene encoding a co-hemolysin.This isolate was confirmed to be sequence type 9.This strain didn’t have the erm(A), erm(B), or mef(A), macrolide resistance genes, but was not susceptible to azithromycin.

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HighlightsThis is the first document concerning human case of bacteremia due to Streptococcus suis serotype 5 in Japan.We confirmed the novel sequence type 752 of this isolate.Both sly (encoding the hemolysin suilysin) and mrp (encoding a muramidase-released protein) were detected with no amplification of epf (encoding the extracellular factor), showing the virulence-associated gene profiling.This isolate had both tet(O) and erm(B) as the antimicrobial resistance genes.

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In this multi-center prospective test-negative case-control study in Japan, the effectiveness of both BA.1-containing and BA.4/BA.5-containing bivalent COVID-19 mRNA vaccines against symptomatic infection during the BA.5-dominant period was high compared to no vaccination (65% and 76%) and moderate compared to monovalent vaccines administered over half a year before (46% combined).