<p class="Default"><strong><em>Introduction</em></strong><em>: Cardiovascular disease (CVD) is a major cause of death and disability worldwide. The most stringent primary CVD screening guidelines in developed countries use absolute CVD risk scores or coronary heart disease, such as Framingham or SCORE (Systematic Coronary Risk Evaluation) there are two types of CVD risk factors namely modifiable risk factors and unmodified risk factors. <strong>The aim</strong> of the current study is to determine the profil of potentially modifiable and unmodified cardiovascular risk factors. <strong>Method</strong>: </em><em>This research consists of 41 elderly people which aged ≥ 60 years in Guguak, Kabupaten 50 Kota, West Sumatera, Indonesia. The data taken is modifiable risk factors consisting of diseases related risk factors </em><em>including blood pressure categories, lipid profile, central obesity, body mass index </em><em>and lifestyle related risk factors such as </em><em>smoking habit</em><em>. We also take data of unmodified risk factors such as age and gender</em><em>. <strong>The result</strong>: t</em><em>his study consists of 41 elderly people which aged ≥ 60 years in Guguak, Kabupaten 50 Kota, West Sumatera, Indonesia. The mean age of  elderly were 68</em><em>±</em><em>7.64861 years old that consisting of 29.3% men and 70.7% women, </em><em>34% of elderly with hypertension, the elderly with hypercholesterolemia 71%, hypertriglyceridemia 41%, and the elderly women with low HDL-C levels were 53%,  the elderly men with low HDL-C levels were 92%. <strong>Conclusion</strong><strong>: </strong>There are two types of risk factors CVD, modifiable risk factors and nonmodifiable risk factors. </em><em>The modifiable risk factors consisting of diseases related risk factors </em><em>including blood pressure categories, lipid profile, central obesity, body mass index </em><em>and lifestyle related risk factors such as </em><em>smoking habit.</em></p>

Background: Malignant breast tumors are a disease where there is overgrowth or uncontrolled development of breast tissue cells. The method of mediating malignant breast tumors up to now which is the gold standard is histopathological examination, which in this examination can determine the type of malignant or benign breast tumors. Histopathological examination of breast tissue is needed as a definitive diagnosis in determining the type of breast malignant tumor and the degree of histopathology. Objective: To determine the histopathological picture of malignant breast tumors at the Pathology Anatomy Laboratory of RSUP. M. Djamil Padang in 2017.Method: This research is a descriptive study with cross sectional design. The sample of this study were 47 people with breast malignant tumors at the Anatomy Pathology Laboratory of Dr. M. Djamil Hospital in 2017 which met the inclusion and exclusion criteria. The research data was obtained from the status of the Pathology Anatomy Laboratory at RSUP.DR.M.Djamil Padang in 2017. Results: The highest frequency of malignant breast tumors in the age group 26-65 years (95.7%), female gender (100%), histopathology type invasive ductal carcinoma (63.8%), histopathological degree (68.1%). Conclusion: The description of the incidence of malignant breast tumors in the laboratory of Dr. M.Djamil Hospital Padang in 2017 mostly occurs at the age of 26-65 years, female, histopathological type of invasive ductal carcinoma, degree II.

Hepatocellular  carcinoma  (HCC)  is  a  malignant  tumor  originating  from  hepatocyte  cells  including  primary malignant tumors of the epithelial liver. Hepatocellular carcinoma is the fifth most malignant in the world and the third largest cause of death of all malignancies. Diagnosis of HCC is obtained from the patient's history, examination  of  the  patient,  by  imaging  (ultrasonography,  MRI  or  CT  scan)  and  an  increase  in  serum  tumor biomarkers of alpha feto protein (AFP) (> 400 ng mL). Early diagnosis is important to increase the patient's life expectancy and only 30-40% of patients are diagnosed at an early stage. Biomarkers in HCC not only help in diagnosing but also predict prognosis or recurrence and in choosing therapy. The stability of miRNA in blood circulation makes miRNA an ideal candidate for use in the diagnosis and treatment of cancer.

Tuberculosis (TB) is a progressive granulomatous infectious disease caused by Gram-positive acid-resistant bacilli classified in the genus Mycobacterium. Tuberculosis in humans is caused by Mycobacterium tuberculosis (MTB) and it mainly infects the lungs, although it can also infect intestines, meninges, bones, lymph nodes, skin that cause extra-pulmonary TB. Tuberculous lymphadenitis is an inflammatory process in lymph nodes as a result of MTB activity. The inflammatory process caused by MTB activity is often associated with anemia as the most common complication. Anemia in TB is caused by an inflammatory process associated with bone marrow suppression due to pro-inflammatory cytokines, thus inhibiting the proliferation and differentiation of erythroid progenitor cells. This chronic TB infection also affects iron hemostasis, thus further affecting the hematological profile of TB patients. This study aimed to determine the hematology profile of TB lymphadenitis patients in the Siti Rahmah Hospital, Padang, Indonesia. This was a descriptive study, with a population of patients diagnosed with TB lymphadenitis based on the results of a fine needle biopsy in the Colli region. The samples of this study consisted of 24 patients who have tested the hematology profile. Tuberculosis lymphadenitis patients in females were higher than males, the mean age was 26.75±19.53 years old dominated by an adult (54%). The mean of 3 hemoglobin levels was 11.8±1.522 g/dL, with 62.5% anemia patients. The mean leukocyte count was 10400±3018.926/mm , 3 with 54.2% of patients had normal levels of leukocyte. The mean of thrombocyte count was 334750±74440.668/mm , with 83.3% in normal levels and the mean of Erythrocyte Sedimentation Rate (ESR) was 35.25±31.489 mm/h, with 54.2% patients in high ESR. Hematology profile in TB lymphadenitis patient was anemia, normal levels of leukocytes, thrombocyte, and increased levels of ESR.

The development of technology information in the 4.0 revolution era also affected to education. Higher education is demanded to develop curriculum based on digital literacy and technology literacy. The use of blended learning combines face-to-face methods with Google classroom in the Modul Pengantar Pembelajaran Kedokteran. The purpose of this study is to find out at the learning experiences of students using blended learning. Methods: This is descriptivestudy with cross sectional design. The study sample was first semester students at the Faculty of Medicine at Baiturrahmah University. Data collected through online questionnaire using Google form. Results: The number of respondents was 56 students. As many as 83.9% of students are familiar with the term e-learning or blended learning, 92.9% stated they did not experience difficulties when using google classroom,as many as 92.9% of students recommend google classroom as an effective media to e-learning. Conclusion: the benefits of blended learning can be felt by students, the media deliver learning resources and discussion with students and examine the results of student assignments quickly, and improve student discipline