Aim. To test the new selenium containing metal complex (Zn2+) compounds by acute hypoxia-hypercapnia method in experiments on mice for antihypoxic effect finding. Methods. The screening of antihypoxants in experiments on mice placed in acute hypoxia-hypercapnia condition (AH + H) among 11 new metal complex selenium containing compounds have been performed. Condition of AH + H in animals was formed by their placing in hermetic glass boxes with 0.25 L free volume. Each substance has been used once by intraperitoneal introduction 60 min. before mice placing in AH + H area in doses 10, 25, and 50 mg/kg. The “life span” parameter was used as a criterion of antihypoxic activity. At the definite steps of investigation all animals where undergone to rectal temperature measuring. Results. The antihypoxic effect was shown by 4 compounds among 11 (πQ2719, πQ2720, πQ2721, πQ2882). The greatest result in life span was found in substance πQ2721. In this case the right positive interaction between doses of substances and results was marked - doses 10, 25 and 50 mg/kg provide life span enlargements to 25.1, 81.7 (р < 0.05), and 186.1% (р < 0.005) in comparison with control groups correspondently. The efficiency of etalon substance πQ1983 was near to that of πQ2721 but in dose 50 mg/kg it becomes weaker in activity than new compound. Conclusion. The test resultant of 11 new metal complex (Zn2+) substance with selenium in structure of ligand in use of acute hypoxia-hypercapnia method shows the πQ2721 as an antihypoxant that was confirmed by significant mice life span enlargement after doses 25 and 50 mg/kg during its action that according with dose-dependent rectal temperature decrease. (For citation: Yevseyev AV, Surmenev DV, Parfenov EA, et al. Testing of new selenium containing metal complex compounds by acute hypoxia-hypercapnia method. Reviews on Clinical Pharmacology and Drug Therapy. 2017;15(4):46-52. doi: 10.17816/RCF15446-52).

ФГБОУ ВО «Смоленский государственный медицинский университет» МЗ РФ, г. Смоленск, Россия 2 ФГБОУ ВО «Российский национальный исследовательский медицинский университет им. Н. И. Пирогова» МЗ РФ, Москва, Россия Цель: изучение влияния экстракорпоральной гемокоррекции на оксидативный стресс и антиоксидантную защиту организма у больных абдоминальным сепсисом� Материал и методы. Обследовано 46 больных� Все пациенты были разделены на две группы� Больным основной группы (n = 23), наряду со стандартной интенсивной терапией и активной детоксикацией (продленной вено-венозной гемофильтрацией), проводили метаболическую терапию сукцинатсодержащими антиоксидантами� Больные контрольной группы (n = 23) получали стандартную интенсивную терапию и активную детоксикацию� Исследование проводили в пять этапов: до гемофильтрации, а также через 1 сут, 3, 5 и 7 сут после ее начала� Результаты. Установлено, что на последнем этапе изучаемые показатели в основной группе отличались от таковых в контрольной, достигая нормальных значений� В контрольной группе существенное улучшение указанных показателей наблюдалось только на V этапе� Вывод. Сочетанное применение традиционной терапии сепсиса, активной детоксикации и метаболической протекторной терапии сукцинатсодержащими антигипоксантами приводит к более быстрому купированию оксидативного стресса, раннему восстановлению активности системы антиоксидантной защиты и нормализации газообмена в легких� Ключевые слова: абдоминальный сепсис, острый респираторный дистресс-синдром, оксидативный стресс, система антиоксидантной защиты организма Для цитирования: Петров В� С�, Петрова М� М�, Свиридов С� В�, Сурменев Д� В� Экстракорпоральная гемокоррекция и ее влияние на свободнорадикальное окисление и антиоксидантную защиту при абдоминальном сепсисе // Вестник анестезиологии и реаниматологии�-2018�-Т� 15, № 1�-С� 40-45�

Aim. Comparative analysis of the efficiency of metal-complex (πQ1983, πQ2721) and aminothiol (Amtizole, Sunazole) antihypoxants in experiments on rats exposed to acute hypoxia with hypercapnia. Methods. Experiments performed on 182 male rats of Wistar line weighing 150-170 g. The study of antihypoxic activity of substances was carried out on the model the AH+Hc. The condition of acute hypoxia in rats was formed by placing them in glass airtight containers with a free volume of 1.0 L. Antihypoxic effect was evaluated by the life expectancy of animals in the described conditions. Substances πQ2721, πQ1983, Amtizole and Sunazole was administered once intraperitoneally at doses of 25, 50 and 100 mg/kg. Previously each substance was dissolved in 0.9% NaCl (1.0 ml). Testing the effectiveness of the substances on AH+Hc model was carried out after 1 h after administration of the substances and after 24 h. Animals of control groups were injected with 1.0 ml of 0.9% NaCl. In animals exposed to test AH+Hc in 1 h after administration were performed measurements of the rectal temperature before the experiment and through 1 h after administration, i.e. before AH+Hc. In animals selected for 24-hour observation, rectal temperature was measured before the experiment, and then after 1, 3, 6, 12, 18 and 24 h of observation, after which they were exposed to AH+Hc. Results. The antihypoxic effect of a selenium-containing substance πQ2721 based on Zn2+ was confirmed in experiments on rats. In a number of substances for comparison the πQ2721 proved himself not only as equally effective. It is found that after 1 h after administration at a dose of 50 mg/kg πQ2721 superior to all studied compounds, including antihypoxant with succinate Sunazole. An important advantage of the new promising antihypoxic agent was the preservation of its action for 24 hours after injection. (For citation: Evseev AV, Surmenev DV, Evseeva MA, et al. Comparative analysis of metal-complex and aminothiol antihypoxants efficiencies in the experiment. Reviews on Clinical Pharmacology and Drug Therapy. 2018;16(2):18-24. doi: 10.17816/RCF16218-24).

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