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BACKGROUND: Due to the long period of use of metronidazole in medical dental practice, today it is relevant to study the sensitivity and the minimum inhibitory concentration of reference and clinical strains of obligate anaerobic microbiota to metronidazole in periodontitis. AIM: Determination of sensitivity and minimum suppressive concentration of reference and clinical strains of obligate anaerobic microbiota to metronidazole in periodontitis. MATERIALS AND METHODS: Strains of obligate anaerobic microbiota of periodontal pockets with moderate periodonitis were isolated from 30 patients. The study was carried out by the cassette micromethod, which is a modification of the method for determining the sensitivity by serial dilution in a dense agar medium. RESULTS: As a result of the study, it was found that many of the microbes found in periodontal pockets have a relatively low sensitivity to metronidazole (MIC from 4 to 12 g / ml). This circumstance is obviously due to the fact that this antibacterial chemotherapy drug has been used for a long time in periodontal practice. CONCLUSIONS: In this regard, in order to increase the effectiveness of local antibacterial therapy, this chemotherapy drug must be combined with antiseptics that have a pronounced antibacterial effect against periodontal pathogenic microflora, for example, Metrogyl Dent gel, containing, along with metronidazole, the antiseptic chlorhexidine, as well as the use of physical hardware methods of exposure to create significant the concentration of the antibacterial drug in the mucous membrane and in the contents of periodontal pockets, which can be done using phonophoresis.

The article presents the results of a microbiological experiment to study the sensitivity of periodontal pathogens to coniferous polyprenols in the preparation of “Solagift”. The optica density of clinical isolates Streptococcus constellatus; Staphylococcus aureus; Fusobacterium nucleatum; Aggregatibacter actinomycetemcomitans during cultivation with the addition of polyprenol concentrate 1:5 was measured during 3-7 days. Comparison criteria: the change in the phase of adaptation (lag-phase), the phase change of geometric growth, the amplitude of the peak phase of geometric growth, the duration of the stationary phase, the period of the withering away of culture. In comparison with the parameters of periodontal pathogens in the control, the presence of coniferous polyprenols led to a significant decrease in the activity of all microbes according to all criteria, especially Staphylococcus aureus, whose growth was completely suppressed.

Background. An irreducible displacement of the articular disc (IDD) is one of the TMJ conditions characterized by complexity of clinical manifestations, severity and is always accompanied by myofascial pain disorders. Objective. To improve the results of treatment of patients with TMJ IDD and myofascial pain syndromes. Methods. We performed a clinical examination and treatment of 38 patients with irreducible displacement of the TMJ articular disc and myofascial pain disorders. As additional research methods, we used CBCT, MRI, EMG. A step-by-step treatment was conducted, including a drug therapy, injection of botulinum toxin type A (BTA) in the masticatory, temporal, lateral pterygoid muscles (LPM) bilaterally; repositional splint therapy; arthrocentesis with the lavage of both articular spaces. Results. The overall effectiveness of the treatment was 97.4%. Out of 38 patients, 34 (89.5%) were treated without arthrocentesis with the complete restoration of the mandibular movement volume and elimination of pain syndrome. Conclusions. An effective system has been developed for a sequential complex treatment of TMJ IDD; a new technique has been developed for a periarticular injection access to the LPM allowing administration of a drug to its upper and lower heads. The high efficiency of BTA injections in the treatment of TMJ IDD is due to the mandatory drug administration into 3 muscles: masticatory, temporal and lateral pterygoid. In the treatment of TMJ IDD, arthrocentesis is effective with lavage of the lower and upper articular spaces.