Honey allergy is a very rare, but serious health condition. In this study, we presented 1 patient who had anaphylaxis after the honey allergological investigation with skin prick-prick test with honey. Honey as a food has been associated to allergic reactions and as the increased consumption of honey in health food may increase the incidence of honey-related allergic reactions.

Describe the safety and long-term use of omalizumab in chronic urticaria (CU), both spontaneous (CSU) and inducible (CIndU). Retrospective chart-review (2006-15) of CU patients treated with omalizumab for ≥ 6 months. Statistical analyses: descriptive statistics, Mann-Whitney, generalized linear models. 23 patients with CSU (3 men), 3 with CIndU (2 men). Generalized linear models showed UAS reduction per omalizumab administration of 16% in CIndU and CSU and UAS7, of 15% in CIndU, and 20% in CSU. DLQI score at baseline had a median of 19 (CIndU and CSU) and after omalizumab a median of 0 (in both). Seven CSU patients stopped omalizumab and remain asymptomatic. No side-effects were observed. Omalizumab is safe and efficacious in CU. Stopping omalizumab can be tried, as some patients achieve remission.

Adverse reactions to iodinated contrast media RESUMOOs meios de contraste radiológico iodados (MCRI) são os meios de contraste mais usados em radiologia e são cada vez mais utilizados na prática clínica. A ocorrência de reações adversas a MCRI é muitas vezes desvalorizada, podendo colocar o doente em risco numa posterior utilização ou, pelo contrário, sobrevalorizada, condicionando restrições desnecessárias. O reconhecimento precoce das reações adversas, assim como a sua fisiopatologia, fatores de risco, abordagem diagnóstica e abordagem terapêutica, são essenciais para um correto manejo dos MCRI. Por esta razão é importante a divulgação deste tema em Imunoalergologia, pela necessidade de abordar e orientar corretamente estes casos. Palavras -chave:Meios de contraste radiológico iodados, reações adversas, reações imediatas, reações tardias, testes cutâneos. ABSTRACTIodinated contrast media (ICM) are the most common contrast agents used in modern radiology and they are becoming more commonly used in medical practice. The occurrence of adverse reactions is frequently undervalued, placing the patient at risk for further exposure. On the other hand, reactions can be overvalued, conditioning unnecessary restrictions. Early recognition of adverse reactions, knowledge of their physiopathology, risk factors and therapeutic approach are essential for a correct management of ICM. This is why it is important to divulge this knowledge among imunoallergologists, who will need to evaluated and treat these cases. R e v P o r t I m u n o a l e r g o l o g i a 2 0 1 9 ; 2 7 ( 1 ) : 9 -2 0 Data de receção /

Food allergy has an estimated prevalence of 6%–8% in children. Meat allergy and multiple food allergy due to sensitization to cross-reactive components in infancy is, however, less frequent. A 5-year-old girl was referred to our department with a multiple food allergy history. She had severe immediate worsening of her atopic dermatitis with hen's egg (6 months) and cow's milk introduction (7 months). At the age of 9 months, she presented with recurrent and reproducible atopic dermatitis' worsening and lip edema with the introduction of different meats (chicken, turkey, cow, pork, and rabbit), having the same complaints with fish at 12 months (salmon and hake). At her first appointment she was avoiding hen's egg, cow's milk, meat, and fish (except fresh tuna, codfish, and pollock). We performed skin prick tests (commercial extract and prick-to-prick with whole food) and specific IgE, which revealed sensitization to hen's egg, raw meat (cow, pork, chicken, turkey, duck, lamb, goat, and rabbit; negative for cooked meat), codfish and cow's milk (mild). ISAC was performed, revealing sensitization to 3 cross-reactive components (serum albumins Bosd6, Canf3, and Feld2) and specific food components of chicken's egg/meat (Gald1, 2, 3, and 5), cod (Gadc1), hazelnut (Cora9), and kiwi (Actd1). We present a rare case of multiple food allergy in infancy, where sensitization to cross-reactive components was responsible for most of the children complaints. The detection of serum albumins' involvement was especially important, because it can possibly mean tolerance to these foods in well-cooked forms, substantially improving patient and family's quality of life.