There is a significant relationship between the types of treatment (topical, oral systemic, phototherapy and biologic therapy) and the number of combinations of treatments and adherence.

Metastatic Crohn's disease is a rare inflammatory process that is non-contiguous from the bowel. It can affect the penis and is variable in presentation and onset in relation to bowel symptoms. It has been treated with oral, topical, systemic, and surgical therapies. We describe our experience with two cases of penile metastatic Crohn's disease and their management in comparison with other cases described in the literature. Both our patients were of the lymphoedematous type and had sexual and voiding dysfunction. They were treated with topical and intra-lesional steroids and circumcision after unsuccessful systemic treatments.

Nongenital warts are benign skin lesions caused by HPV infection and can be easily treated in primary care. Our Drug review presents the different clinical types and discusses the properties and efficacy of the available treatment options, followed by sources of further information. Copyright © 2012 Wiley Interface Ltd

Objective: To compare the effects of antiviral therapy such as sofosbuvir and daclatasvir in HCV patients which were diagnosed by HCV-RNA PCR without Diabetes Melitis. Study Design:  Cross-sectional comparative study Inclusion Criteria: HCV Positive patients after PCR test conformation between 20-75 years age. Methodology: In this cross-sectional analysis total of 100 Hepatitis c infected patients selected, Sofosbuvir plus Daclatasvir treatment given for 03 months period. Different parameters were recorded such as Total Bilirubin, Direct Bilirubin, Indirect Bilirubin, Hb levels, Serum ALT levels, and Serum ALP level. The statistical relation of the mentioned variables was analyzed through SPSS version 15. Results: Out of a total of 100 patients, 47% (47) were males, 53% (53) were females, 44% (44) patients had a history of prior interferon therapy, 23% (23) patients were having low hemoglobin levels before starting treatment. Both groups completed oral antiviral treatment for 12 weeks & resulting data showed the equality of treatment on group B and group A as no decrease in hemoglobin (p=0.799), ALT normalization (p=1.000) & no rise in serum bilirubin (p=0.817) during 1st month of treatment was noted in both groups while the SVR noted of both groups also showed no significant difference to each other i.e. 92% & 94 % (p=0.696). Conclusion:  This study concluded to monitor the anti-viral drug response against HCV patients.

Background: High mortality rate around the globe has been reported due to diarrheal disease among all fewer than five years of age. Many studies show their utilization in the treatment of diarrheal disease especially among children of under-five. Objective: To assess the treatment outcome of diarrhea with and without probiotics among children aged 12-60 months. Methodology: This comparative cross-sectional study was undertaken from July to December 2017. A pre-designed questionnaire was used to collect the information in terms of antibiotics, rehydrating agents, antipyretic agents, and probiotics. A total of 109 patients were selected randomly and then divided into two groups as "probiotic" having 55 children and "Non-Probiotic", having 54 children. Guardians of patients were contacted telephonically after 48 hours and 72 hours to ask about the time frame of relief from symptoms, diarrheal episodes, and cure from disease. Data were analyzed by using SPSS 20. Results: Out of 109 patients, 54 patients were in the non-probiotic group and 55 in the probiotic group. The overall age of patients remained 31±12 months. Saccharomyces boulardii (56.4%) and Lactobacillus GG (43.6%) were probiotics prescribed by pediatric physicians. A significant difference (p=0.000) was observed in terms of treatment outcome showing early relief (12 hrs) 43 (78%) vs 22 (41%) in probiotic vs non-probiotic group and early cure (<48 hrs) from diarrhea in probiotic group 48 (87%) vs 35 (65%) as compared to the non-probiotic group. (p=0.00) Conclusion: The use of probiotics during the treatment of acute diarrhea among children below five years shortens the duration of symptoms and helps the cure as early as one day before the patients' not using probiotics.