Using Chilean data for fourth grade students, this research studies the effect of competition among schools on the results of standardized tests, academic self-esteem and motivation, the climate within the school, civic participation and training, and healthy lifestyle habits. In order to address the potential bias due to the endogeneity of the competition among schools, an instrumental variable approach is implemented, using instruments associated with the size of each "educational market." The results show that an increase of one standard deviation in competition among schools generates a moderate increase in standardized test results (0.06 standard deviations) and a more significant decrease in the other indicators of quality (between 0.02 and 0.16 standard deviations). Therefore, the results suggest a tension in the school between various objectives of educational policy, in which pressure to improve standardized test scores resulting from competition among schools could produce an undesired effect of deterioration in other dimensions of quality.
Vibrio anguillarum phage CHOED was isolated from Chilean mussels. It is a virulent phage showing effective inhibition of V. anguillarum. CHOED has potential in phage therapy, because it can protect fish from vibriosis in fish farms. Here, we announce the completely sequenced genome of V. anguillarum phage CHOED.
Expression of the bHLH transcription protein Atoh7 is a crucial factor conferring competence to retinal progenitor cells for the development of retinal ganglion cells. Several studies have emerged establishing
ATOH7
as a retinal disease gene. Remarkably, such studies uncovered
ATOH7
variants associated with global eye defects including optic nerve hypoplasia, microphthalmia, retinal vascular disorders, and glaucoma. The complex genetic networks and cellular decisions arising downstream of
atoh7
expression, and how their dysregulation cause development of such disease traits remains unknown. To begin to understand such Atoh7‐dependent events in vivo, we performed transcriptome analysis of wild‐type and
atoh7
mutant (
lakritz
) zebrafish embryos at the onset of retinal ganglion cell differentiation. We investigated in silico interplays of
atoh7
and other disease‐related genes and pathways. By network reconstruction analysis of differentially expressed genes, we identified gene clusters enriched in retinal development, cell cycle, chromatin remodeling, stress response, and Wnt pathways. By weighted gene coexpression network, we identified coexpression modules affected by the mutation and enriched in retina development genes tightly connected to
atoh7
. We established the groundwork whereby Atoh7‐linked cellular and molecular processes can be investigated in the dynamic multi‐tissue environment of the developing normal and diseased vertebrate eye.
Lactococcus lactis is a common inhabitant of the intestinal microbiota of salmonids, especially those in aquaculture systems. Here, we present a genome sequence of a Lactococcus lactis strain isolated from the intestinal contents of rainbow trout reared in Chile.
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