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Focusing on the interplay between interface chem-1 istry, electrochemistry, and integrated electronics, we show a 2 novel low-cost and flexible biosensing platform for continuous 3 glucose monitoring. The amperometric biosensing system features 4 a planar three-electrode structure on a plastic substrate, and 5 a wireless NFC-powered electronic system performing sensor AQ:1 6 analog front-end, A/D conversion, digital control, and display 7 tasks. The working electrode is made of electropolymerized poly 8 (3,4-ethylenedioxythiophene) film onto a polyethylene terephtha-9 late/gold electrode followed by immobilization of cross-linked 10 glucose oxidase by glutaraldehyde. The advantages offered by 11 such a device, including low-cost materials and instrumentation 12 as well as the good sensitivity of 9.24 µA/(mM • cm 2) are 13 promising tools for point-of-care monitoring. It is demonstrated 14 that the devices are good candidates for the development of 15 advanced sensing approaches based on the investigation of the 16 noise produced during operation (fluctuation-enhanced sensing).

In this work, we investigate some major issues for the use of silicon photomultiplier (SiPM) devices in continuous wave functional near-infrared spectroscopy (CW fNIRS). We analyzed the after-pulsing effect, proposing the physical mechanism causing it, and determining its relevance for CW fNIRS. We studied the SiPM transients occurring as the SiPM device goes from the dark (LED in off state) to the illumination (LED in on state) conditions, and vice-versa. Finally, we studied the SiPM SNR in standard CW fNIRS operation.

This work introduces a compact DC model developed for Organic Thin Film Transistors (OTFTs) and its SPICE implementation. The model relies on a modified version of the Gradual Channel Approximation (GCA) that takes into account the contact effects, occurring at non-ohmic metal/organic semiconductor junctions, modeling them as reverse biased Schottky diodes. The model also comprises channel length modulation and scalability of drain current with respect to channel length. To show the suitability of the model, we used it to design an inverter and a ring oscillator circuit. Furthermore, an experimental validation of the OTFTs has been done at the level of the single device as well as with a discrete-component setup based on two OTFTs connected into an inverter configuration. The experimental tests were based on OTFTs that use small molecules in binder matrix as an active layer. The experimental data on the fabricated devices have been found in good agreement with SPICE simulation results, paving the way to the use of the model and the device for the design of OTFT-based integrated circuits.

We built a fiber-less prototype of an optical system with 156 channels each one consisting of an optode made of a silicon photomultiplier (SiPM) and a pair of light emitting diodes (LEDs) operating at 700 nm and 830 nm. The system uses functional near-infrared spectroscopy (fNIRS) and diffuse optical tomography (DOT) imaging of the cortical activity of the human brain at frequencies above 1 Hz. In this paper, we discuss testing and system optimization performed through measurements on a multi-layered optical phantom with mechanically movable parts that simulate near-infrared light scattering inhomogeneities. The baseline optical characteristics of the phantom are carefully characterized and compared to those of human tissues. Here we discuss several technical aspects of the system development, such as LED light output drift and its possible compensation, SiPM linearity, corrections of channel signal differences, and signal-to-noise ratio (SNR). We implement an imaging algorithm that investigates large phantom regions. Thanks to the use of SiPMs, very large source-to-detector distances are acquired with a high SNR and 2 Hz time resolution. The overall results demonstrate the high potentialities of a system based on SiPMs for fNIRS/DOT human brain imaging applications.