The Wine Pomace Products (WPP) prevent the increase of endothelial permeability induced by INF-γ and increase E-cadherin expression in the cell junctions.

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The use of winery by-products, such as wine pomace, to improve human health is attracting increasing interest. The wine pomace is the mainly winery by-products consisted of seeds and skins that suppose an economic and environmental problem and their use as functional ingredient or for pharmaceutical purposes are being increasingly recognized as a good and inexpensive source of bioactive compounds. In this sense, it known the potential health properties of wine pomace products in the prevention of disorders associated with oxidative stress and inflammation such as endothelial dysfunction, hypertension, hyperglycemia, diabetes, obesity, etc. Those effects are due to the bioactive compounds of wine pomace, involved in the maintaining of the cell redox balance through the modulation of oxidative stress and inflammatory process. The mechanisms concern especially modulation of antioxidant/prooxidant activity, improvement of nitric oxide bioavailability, reduction of proinflammatory cytokines and modulation of antioxidant/inflammatory signal pathways. This review mainly summarizes the studies that examine the mechanisms of wine pomace products as modulators of oxidative status involved in cell pathologies as well as their potential therapeutic use for cardiovascular diseases. For this purpose, the review provides an overview of the findings related to the wine pomace bioactive compounds profile, their bioavailability and the action mechanisms through which them maintain the redox cell balance involved in health benefits. The review suggests an important role for wine pomace product in cardiovascular diseases prevention and their regular food intake may to attenuate the development and progression of comorbidities associated to cardiovascular diseases.

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