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1. Our experiments show that an intravenous injection of antigen immediately after an intravenous injection of antiserum in the guinea-pig were followed by:(a) Acute shock and death within 5 min. The signs and post-mortem appearances were indistinguishable from acute anaphylactic shock as typically seen in the guinea-pig. Some control animals injected with antiserum only died in a way similar to those which received both antiserum and antigen. These are discussed in detail in the body of the paper.(b) Delayed shock and death some hours later. The post-mortem appearances were those of gastro-intestinal congestion and haemorrhage resembling the changes seen in dogs dying of anaphylactic shock. Such changes were never seen in the control animals.(c) Recovery. Practically all the animals which recovered had symptoms of respiratory embarrassment immediately following the injections of anti-serum and antigen and many had later symptoms of abdominal shock. The animals which were given an injection of antiserum only rarely had any symptoms and never abdominal symptoms.2. It is necessary to test the antisera used by control inoculation since some antisera are toxic.

THE patient, a soldier aged 22, was wounded in the back and right shoulder by shrapnel on 30th March 1917. The only serious damage was a laceration of the right kidney. This was successfully treated. He received prophylactic injections on 30th Narch, 4th April and 20th April. No symptoms were produced by the second and third injections. On 2nd May, about eleven o'clock, he was given his fourth dose of serum, 500 units. Almost immediately he called out that he felt very ill. He became cyanosed, and began to vomit. The cyanosis increased, breathing became difficult, there was a thick secretion of tenacious niucus in the upper respiratory passages, the pulse could not be felt. Hot cloths and massage were applied to the precordial area. Artificial respiration was performed for about twenty minutes. The lips and eyelids were edematous. After twenty minutes respiration commenced, and continued for about an hour. During this period no heart action could be detected. The body was that of a well-nourished and well-developed young man. There was no cyanosis or cedema at the time of the post-mortem examination. Over the back of the right loin was an incision which had almost completely healed, but had broken down at one point where a few drops of blood had exuded. Over the right hypochondrium was a small superficial scar, about 1 in. by 1 in., brownish in appearance, and probably the result of a superficial burn. The superficial veins were engorged, but no other change was noted in the brain and membranes. There was no excess of fluid in the ventricles or subarachnoid space. ik'outh and Neck.-The tonsils were enlarged. The cesophagus was normal. The larynx and trachea were congested, and contained a large quantity of tenacious mucus. The lymphatic glands of the neck were enldrged, pale and soft. The heart weighed 12+ oz. The heart muscle, valves, and the great vessels were normal. There was no trace of thymus tissue. Except for some slight congestion of the posterior part of the lower lobes, the l u g s were normal in appearance. There were numerous enlarged glands in the mecliastinum ; these were soft and pale. Ether was injected. He died at ten minutes past twelve. The post-mortem was made during the afternoon of the same day. The Brain weighed 49 oz. Thorax.-The pericardium contained about an ounce of clear fluid. The right lung weighed 13 oz., the left lung lo$ 02.