Cataracts are one of the most causes of blindness in the world. Oxidative stress can form pathological conditions such as cataracts. This oxidative stress ability can be measured by the malondialdehyde (MDA) biomarker. Binahong leaves (Anredera cordifolia (Tenore) Steenis) are native plants from Indonesia that are used to treat various diseases including cataract treatment. Binahong leaf (Anredera cordifolia (Tenore) Steenis) has a high amount of flavonoids and is rich in antioxidants that can be used to treat cataracts. Objective. The purpose of this study was to assess the effect of binahong leaf extract on the levels of MDA in a goat lens with cataract-induced material. Method. As many as possible, 40 goat eye lenses were divided into several groups, namely, group I normal lenses as controls (glucose 5.5 mM), group II lenses were cataract induced with glucose concentration of 55 mM, group III lenses with glucose 55 mM + binahong leaf extract (100 μg/ml), group IV lens with glucose 55 mM + binahong leaf extract (200 μg/ml), and group V lens with glucose 55 mM + quercetin (positive control). Biochemical parameters measured in the lens homogenate are malondialdehyde lens morphology in all groups’ observations and comparisons made. Results. The results of the study found that the lens group with the addition of binahong extract showed more results transparency compared to lens groups induced by glucose concentrations of 55 mM). This shows that the diabetic cataract group experienced high oxidative stress due to the accumulation of sorbitol compounds derived from glucose which caused turbidity in the goat eye lens and increased levels of lens MDA. Binahong levels at concentrations of 100 or 200 can inhibit MDA production. Conclusion. Binahong (Anredera cordifolia (Tenore) Steenis) extract has the ability to inhibit the production of MDA levels. In glucose-induced goat lenses, binahong extract and quercetin show antioxidant and anticataract properties.

Latar belakang: Indonesia dengan populasi penduduk terbanyak keempat di dunia. Indonesia mengalami peningkatan penyakit degeneratif yang dapat mempengaruhi kualitas hidup seseorang. Kualitas hidup mencerminkan kepuasan seseorang terhadap kehidupannya secara keseluruhan. Kualitas hidup terdiri dari empat aspek/dimensi, diantaranya dimensi fisik, dimensi psikologis, dimensi sosial dan dimensi lingkungan. Salah satu aspek dari dimensi psikologis yaitu spiritual. Semakin baik kondisi spiritual seseorang, maka semakin baik kesejahteraan psikologisnya. Secara umum, kualitas hidup dipengaruhi oleh usia, jenis kelamin, pendidikan terakhir, status pernikahan, pekerjaan, penghasilan, hubungan dengan orang lain serta standar rujukan. Penelitian ini bertujuan untuk menganalisis kualitas hidup jamaah shalat Subuh. Metode: Penelitian ini bersifat analitik dengan rancangan penelitian cross sectional. Subjek penelitian berjumlah 77 orang jamaah shalat Subuh yang diperoleh dengan menggunakan metode accidental sampling. Variabel dependen yaitu kualitas hidup, variabel independen yaitu usia, jenis kelamin, pendidikan terakhir, status pernikahan, pekerjaan, penghasilan, kesehatan, dan riwayat penyakit kronis. Kualitas hidup diukur dengan menggunakan kuesioner WHOQoL-BREF yang sudah diterjemahkan. Data yang terkumpul dianalisis secara statistik menggunakan uji Chi-square. Hasil: Sebagian besar responden memiliki dimensi fisik yang buruk (64.9%), dimensi psikologis yang buruk (51.9%), dimensi sosial yang baik (66.2%), dan dimensi lingkungan yang baik (63.6%). Kesimpulan: Variabel yang memiliki hubungan dengan dimensi fisik kualitas hidup yaitu penghasilan (p value=0.007). Variabel yang memiliki hubungan dengan dimensi psikologis kualitas hidup yaitu pendidikan terakhir (p value=0.008) dan penghasilan (p value=0.049). Tidak ada variabel yang memiliki hubungan dengan dimensi sosial kualitas hidup. Variabel yang memiliki hubungan dengan dimensi lingkungan kualitas hidup yaitu pendidikan terakhir (p value=0.031) dan penghasilan (p value=0.005).

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Cataracts are of concern to the world as one of the diseases that cause blindness. Diabetes mellitus has a relationship with cataracts due to hyperglycemia through polyol pathways that are converted to sorbitol by the aldose reductase enzyme. Polyol pathway has implications for the pathogenesis of the formation of diabetic cataracts. The use of anticataract drugs using plants is considered as a solution for the formation of diabetic cataracts. Several studies on plant material have been developed for the treatment of diabetic cataracts that assess the performance potential of bioactive compounds through inhibition of the enzyme Aldose Reductase. Studies from various recent research results provide information that plants as natural products have the potential for a large solution of diabetes cataract prevention and treatment.