BACKGROUND: Chromosomal abnormalities are more common in first trimester recurrent miscarriages (RM). Chromosomal anomalies affect approximately 2%-8% of couples with RM. OBJECTIVES: Evaluate the spectrum and the frequencies of chromosomal anomalies in RM. DESIGN: A retrospective hospital record-based descriptive study. SETTING: A tertiary care center in Turkey. PATIENTS AND METHODS: We studied couples with RM between October 2020 and January 2022. Relevant family and medical history, clinical examination and the results of karyotype were statistically analyzed. MAIN OUTCOME MEASURES: Prevalence and types of chromosomal aberrations in couples with RM. SAMPLE SİZE: 362 couples with a history of RM RESULTS: Among the 362 couples, 14 cases (3.86%) had chromosome abnormalities. Eight cases (57.14%) were structural anomalies and six cases (42.86%) were numerical chromosomal aberrations. We found five balanced translocations (67.5%) and three Robertsonian translocations (37.5%). The prevalence of polymorphic variants was 51/362 (14.1%). CONCLUSIONS: This study supports the conclusion that clinicians should understand the importance of chromosome analysis in these couples and direct them to karyotyping after two abortions in order to exclude the possibility of a genetic cause of RM. LIMITATIONS: Single-center study and retrospective. CONFLICT OF INTEREST: None.

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ResultsIn our study, the mean of LAP index in the patients and the control group were respectively (38,2±42,6 and 12,0±13.1, p=0,000), TG (115,9±67,9 mg/ dl and 82,8±46,3 mg/dl, p=0,004), HOMA-IR (3,5±2,4 and 2,2±1,3 p=0,01), total cholesterol( 178,2± 35,4 mg/ dl and 160,0±27,7 mg/dl p=0,02), insulin (6,1±10,1µU/ml and 11,0±6,3 µU /ml p=0,02), The positive correlation were detected among BMI and LAP index (r=0,73 p=0,000), HOMA-IR (r=0,48 p=0,000), fasting insulin levels ( r=0,46 p=0,000) respecttively . ConclusionHigh LAP index may help for the evaluation of metabolic risk in women with PCOS. In our study, we also determined positive correlations LAP index and other metabolıc parameters.such as TG, LDL-C, HOMA-IR and fasting insulin levels. Increment of LAP may be associated with high cardiovascular risc.