ObjectiveThe aim of this study was to investigate the association of total cerebral small vessel disease (cSVD) score with the risk of intracerebral hemorrhage (ICH) in patients with acute ischemic stroke who received intravenous thrombolysis (IVT) using recombinant tissue-plasminogen activator (rt-PA).MethodsWe retrospectively reviewed clinical data from two stroke registries of patients with acute ischemic stroke treated with IVT. We assessed the baseline magnetic resonance (MR) visible cSVD markers and total cSVD score (ranging from 0 to 4) between patients with and without ICH after IVT. Logistic regression analysis was used to determine the association of total cSVD score with the risk of ICH after IVT, adjusted for cofounders selected by least absolute shrinkage and selection operator (LASSO). We additionally performed an E-value analysis to fully explain away a specific exposure-outcome association. Receiver operating characteristic (ROC) curve analysis was used to quantify the predictive potential of the total cSVD score for any ICH after IVT.ResultsAmong 271 eligible patients, 55 (20.3%) patients experienced any ICH, 16 (5.9%) patients experienced a symptomatic ICH (sICH), and 5 (1.85%) patients had remote intracranial parenchymal hemorrhage (rPH). Logistic regression analysis showed that the risk of any ICH increased with increasing cSVD score [per unit increase, adjusted odds ratio (OR) 2.03, 95% CI 1.22–3.41, P = 0.007]. Sensitivity analyses using E-value revealed that it would need moderately robust unobserved confounding to render the exposure-outcome (cSVD-any ICH) association null. ROC analysis showed that compared with the National Institutes of Health Stroke Scale (NIHSS) score alone, a combination of cSVD and NIHSS score had a larger area under the curve for any ICH (0.811, 95% CI 0.756–0.866 vs. 0.784, 95% CI 0.723–0.846, P = 0.0004).ConclusionThe total cSVD score is associated with an increased risk of any ICH after IVT and improves prediction for any ICH compared with NIHSS alone.

Transmission line is an important part of power system, and sag is an important parameter to evaluate the running state of transmission line. Because of the complex system and the high power consumption of online monitoring application used nowdays, this paper proposes an online sag monitoring system based on high precision barometer and relative height measurement method. Firstly, precision barometer will be installed in the middle of line to calculate the relative height of measuring points. Secondly, the span of space distribution can be calculatd which leads to complete the sag calculation. All the research above has passed the test.

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We propose a 2 π -double-helix point spread function ( 2 π -DH-PSF) using the Fresnel zone approach that can rotate 2 π rad. When 16 Fresnel zones are used, the particles can be tracked in the axial range of 10 µm in a 100 × microscopy imaging system ( N A = 1.4 , λ = 514 n m ). We measured the diffusion coefficient of nanospheres in different concentrations of glycerol with the 2 π -DH-PSF, and the error between the measured results and theoretical value was within 10%, indicating the superior performance of 2 π -DH-PSF in 3D localization imaging of nanoparticles. When combined with the defocus phase, the rotation angle can reach 4 π rad, four times that of the conventional DH-PSF.