Except for hepatitis B virus (HBV), there have been few data on serological markers of hepatitis viruses such as hepatitis C virus (HCV) and E virus (HEV), and human immunodeficiency virus type-1 (HIV) in Bali, Indonesia. During 5 months from April to August 2003, sera were collected from 2,450 pregnant women at eight jurisdictions in Bali, and they were tested for markers of these viruses. Only one (0.04%) was positive for antibody to HCV, but none for antibody to HIV. Hepatitis B surface antigen (HBsAg) was detected in 46 (1.9%) at a prevalence significantly lower than that in 271 of the 10,526 (2.6%) pregnant women in Bali surveyed 10 years previously (P < 0.045). The prevalence of hepatitis B e antigen in pregnant women with HBsAg decreased, also, from 50% to 28% during the 10 years (P < 0.011). Antibody to HEV (anti-HEV) was examined in 819 pregnant women who had been randomly selected from the 2,450. The overall prevalence of anti-HEV was 18%, and there were substantial regional differences spanning from 5% at Tabanan district to 32% at Gianyar district. Furthermore, the prevalence of anti-HEV differed substantially by their religions. In the Sanglah area of Denpasar City, for instance, anti-HEV was detected in 20 of the 102 (20%) Hindus, significantly more frequently than in only 2 of the 101 (2.0%) Muslims (P < 0.001). Swine that are prohibited to Muslims, therefore, is likely to serve as a reservoir of HEV in Bali. In conclusion, HBV is decreasing, HCV and HIV have not prevailed, as yet, while HEV is endemic probably through zoonotic infection in Bali.

Introduction: Leucorrhea was a prolonged problem that has been experienced by women, especially teenagers. Teenagers are part of a population that are at risk. Pathological leucorrhea which is not prevented and handled properly can cause various disease and have a fatal end. This research aimed to know how were the knowledge, attitudes, and behavior of vaginal hygiene towards pathological leucorrhea phenomenon on first grade female students in 1 Senior High School of Denpasar City. Method: This research was a descriptive study with cross-sectional method. The research subject was 106 first grade female students in 1 Senior High School of Denpasar City. The data were collected on 26 th of July 2018. This research used primary data from the questionnaire that had been filled out. Result: The results showed that the level of knowledge about vaginal hygiene was 99,9% good and 0,1% bad. The level of attitudes about vaginal hygiene was 100% good. The level of behavior about vaginal hygiene was 98,2% good and 1,8% bad. Conclusion: Most of the student in Senior High School 1 Denpasar have a good level of knowledge, attitude, and behavior towards vaginal hygiene.

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IntroductionInsulin-like growth factor-binding protein 2 (IGFBP2) plays an important role in the pathogenesis of ovarian cancer. The most prominent effects of IGFBP2 include promoting proliferation, driving invasion, and suppressing apoptosis. This study aimed to determine the diagnostic accuracy of serum IGFBP2 in differentiating between benign and malignant ovarian neoplasms.MethodsPreoperative serum IGFBP2 level was evaluated from 76 women with primary ovarian tumor who underwent exploratory laparotomy at Sanglah General Hospital, Denpasar, Bali, Indonesia. The optimal threshold value of IGFBP2 for the diagnosis of ovarian cancer was determined from the receiver 0perating characteristic (ROC) curve. The diagnosis was confirmed by histopathologic analysis of resected ovarian specimens.ResultsForty-six (60.5%) patients were diagnosed with ovarian cancer. The area under the ROC curve (AUC) of IGFBP2 in detecting ovarian cancer was 0.815 (95% CI: 0.721 to 0.910, P<0.001). For a given specificity larger than 95%, the optimal sensitivity was 63%. The optimal threshold value of IGFBP2 for the diagnosis of ovarian cancer was 804 ng/mL [sensitivity 63%, specificity 96.7%, positive predictive value (PPV) 96.7%, negative predictive value (NPV) 63%, accuracy 76.3%, and diagnostic odd ratio (DOR) 49.5 (95% CI 6.1 to 396.5)]. In a subgroup analysis, IGFBP2 showed excellence performance in diagnosing advanced ovarian cancer (AUC 0.904 [95% CI: 0.806 to 1.000], sensitivity 83.3%, specificity 96.7%, PPV 95.2%, NPV 87.9%, accuracy 90.7%, and DOR 145.0 [95% CI 15.0 to 1395.3]).ConclusionIGFBP2 is a novel and potentially promising biomarker for detecting ovarian cancer. Further studies are needed to confirm its diagnostic performance in premenopausal women and for detecting early stage ovarian cancer.

Introduction: Preterm labor is still a global problem because it affects perinatal morbidity and mortality, especially in developing countries. An increase in hs-CRP in pregnant women is associated with the incidence of preterm labor. This study was conducted to prove that high serum hs-CRP levels are a risk factor for preterm labor. Method: The method used in this study is an observational case-control study, in which pregnant women with preterm labor are in cases group, whereas preterm pregnant women that are not in labor, included in control group. Cases and controls were not matched in the gestational age variable. In both groups blood samples were taken. Blood sampling was taken in the cubital vein to examine the serum levels of hs-CRP. From the data collected, data analysis was performed using SPSS version 23.0. In this study, after the data normality test was performed using the Shapiro-Wilk test, the result p values <0.05 or abnormal distribution data, the Mann Whitney test was chosen. A Chi-square test was performed to determine the increase in serum hs-CRP levels as a risk of preterm labor. Result: hs-CRP levels as a risk of preterm labor. Calculation of the OR is 19.46 times with 95% CI: 2.25-168.27. Conclusion: it can be concluded that high levels of hs-CRP as a risk factor for preterm labor.