The authors reviewed literature on influence of occupational vibration on workers. The data presented cover changes of antioxidant, immune and hormonal state, central nervous system disorders, alterations of hemopoiesis, muscular and connective tissues.

The diagnostic significance of hormones and integral indices of pituitary-adrenal, pituitary-thyroid and pituitary-gonadal system and carbohydrate metabolism (ACTH (corticotropin), aldosterone, cortisol, TSH (thyroid-stimulating hormone), free triiodothyronine (fT3), free thyroxine (fT4), luteinizing hormone (LH), follicle-stimulating hormone (FSH), total and free testosterone, insulin, integral pituitary-adrenal index (IPAI), the pituitary-thyroid index (PTI), indices of carbohydrate metabolism (Caro and HOMA-IR) was studied for the early diagnostics of disorders of neurohumoral regulation in workers of mining and mechanical engineering industries. The most informative indices, permitting to identify disorders of carbohydrate metabolism are established to be indices of insulin resistance (index Caro and index NOMA-IR) and the determination of insulin in serum. For the identification of changes in pituitary adrenal, pituitary-thyroid and pituitary-gonadal system in patients with vibration disease, sensory-neural hearing loss, comorbidity indexes IGNI, ITI, concentrations of LH and total testosterone are of the most diagnostically significance.

Introduction. Unfavourable factors of the working environment affect bone tissue, increasing the risk of developing osteoporosis in workers of harmful industries, which is an urgent social and hygienic problem due to the high prevalence and severity of medical and social consequences. The aim of the study was to investigate the impact of industrial vibration and physical overload on the markers of bone metabolism in industrial workers. Materials and methods. One hundred fifty-two employees of mining and mechanical engineering enterprises in contact with industrial vibration and physical overload were examined. The assessment of bone tissue metabolism in the workers was carried out by the method of solid-phase enzyme immunoassay to determine biochemical markers of bone metabolism: bone alkaline phosphatase, osteocalcin, C-terminal serum telopeptide, cathepsin K, as well as indicators of calcium-phosphorus metabolism. X-ray densitometry was used to assess bone mineral density. Results. There was a significant decrease in the markers of osteogenesis: the concentration of CSF (14.26 ± 4.13 and 18.69±5.28, respectively, p< 0.05) and osteocalcin (12.23±4.15 and 17.84±5.17, respectively, p < 0.05) and an increase in the markers of bone resorption: the level of beta-CrossLaps (0.629±0.162 and 0.361±0.095, respectively, p = 0.002) and the level of cathepsin K (12.49±5.28 and 0.59±0.02, respectively, p < 0.001) in workers of industrial enterprises exposed to physical factors of production. The correlation between the markers of bone metabolism and the experience of exposure to adverse working conditions was established. Conclusion. Combined exposure to physical labour factors is a predictor of calcium-phosphorus metabolism and bone metabolism disorders, increasing the risk of metabolic osteopathy in industrial workers.

Introduction: Health maintenance in workers implies assessment of occupational risks and development of techniques of their elimination in order to increase labor efficiency and working life expectancy. Objective: To develop the system for maintaining health of social workers based on occupational risk assessment and management. Materials and methods: In 2019–2022, studies of working conditions, socio-demographic status, and psychological wellbeing of social workers were conducted in the clinic of F.F. Erisman Federal Research Center for Hygiene. Results: We established groups of social workers at risk of health disorders, such as common diseases and various manifestations of occupational burnout, including groups with null, early, and severe signs of job burnout, and elaborated programs for disease prevention incorporating targeted techiques of health maintenance. Conclusion: We provide a rationale for the system of preserving physical and mental health of social workers that contains various modules aimed at optimizing working conditions, mitigating risk factors, preventing health disorders, including occupational burnout, and promoting a healthy lifestyle.

The study presented describes formation of osteopenic syndrome in workers exposed to physical overexertion and general vibration that is associated with changes in bone metabolism and in mineral density of bone tissue. The data obtained prove bone metabolism to be influenced by pituitary and thyroid system hormones in patients with occupational lumbosacral radiculopathy.