in recent years, there is a growing interest towards the green synthesis of metal nanoparticles, particularly from plants; however, yet no published study on the synthesis of Zno.nps using the Deverra tortuosa extract. through this study, zinc oxide nanoparticles (Zno.nps) have been synthesized based on using the environmentally benign extract of the aerial parts of D. tortuosa as a reducing and capping agent. ZnO.NPs synthesis was confirmed using UV-Visible (UV-Vis) spectroscopy, Fourier Transform Infrared Spectroscopy (FTIR), X-ray Diffraction (XRD) and High Resolution-Transmission electron Microscope (HR-teM). the qualitative and quantitative analyses of plant extract were done. the potential anticancer activity was in vitro investigated against two cancer cell lines (human colon adenocarcinoma "Caco-2" and human lung adenocarcinoma "A549") compared to their activities on the human lung fibroblast cell line (WI38) using the MTT assay. Both the aqueous extract and ZnO.NPs showed a remarkable selective cytotoxicity against the two examined cancer cell lines. Scientific RepoRtS |(2020) 10:3445 | https://doi.

No abstract

In continuation of our previous work, a series of novel thiophene derivatives 4, 5, 6, 8, 9, 9a, 9b, 9c, 9d, 9e, 10, 10a, 10b, 10c, 10d, 10e, 11, 12, 13, 14, 15, 16 were synthesized by the reaction of ethyl 2‐amino‐4,5,6,7‐tetrahydrobenzo[b]thiophene‐3‐carboxylate (1) or 2‐amino‐4,5,6,7‐tetrahydrobenzo[b]thiophene‐3‐carbonitrile (2) with different organic reagents. Fusion of 1 with ethylcyanoacetate or maleic anhydride afforded the corresponding thienooxazinone derivative 4 and N‐thienylmalimide derivative 5, respectively. Acylation of 1 with chloroacetylchloride afforded the amide 6, which was cyclized with ammonium thiocyanate to give the corresponding N‐theinylthiazole derivative 8. On the other hand, reaction of 1 with substituted aroylisothiocyanate derivatives gave the corresponding thiourea derivatives 9a, 9b, 9c, 9d, 9e, which were cyclized by the action of sodium ethoxide to afford the corresponding N‐substituted thiopyrimidine derivatives 10a, 10b, 10c, 10d, 10e. Condensation of 2 with acid anhydrides in refluxing acetic acid afforded the corresponding imide carbonitrile derivatives 11, 12, 13. Similarly, condensation of 1 with the previous acid anhydride yielded the corresponding imide ethyl ester derivatives 14, 15, 16, respectively. The structures of newly synthesized compounds were confirmed by IR, 1H NMR, 13C NMR, MS spectral data, and elemental analysis. The detailed synthesis, spectroscopic data, LD50, and pharmacological activities of the synthesized compounds are reported.

Synthesized from 2-Amino-4,5,6,7-tetrahydro--N-phenylbenzo[b]thiophene-3-carboxamide. -The synthesis of a series of condensed thiophenes uses compounds (I) and (VI) as starting materials. All compounds show potent antiarrhythmic, antianxiety, and serotonin antagonist activities. The thiophene nucleus is essential for activity, and increasing the number of sulfur or nitrogen atoms sharply increases the activities. In addition, the olefinic bond in the substituted side chain leads to an increase of activity. -(AMR*, A. E.-G. E.; SHERIF, M. H.; ASSY, M. G.; AL-OMAR, M. A.; RAGAB, I.; Eur. J. Med. Chem. 45 (2010) 12, 5935-5942, http://dx.doi.org/10.

Reaction of benzylidene cyanoester 1 with thiosemicarbazide, cyanoacetamide, urea and thiourea was resulted in triazepine 2, pyridine 5, oxopyrimidine 6, and thiooxopyrimidine 8, respectively. Triazepine 2 was reacted with chloroacetic acid and/or chloroacetamide to give thiazolotriazepine 3 and acetamide 4. Reaction of thiopryrimidine 8 with hydrogeneperoxide affording pyrimidins 9 and with chloroacetic acid and chloroacetamide yielded thiazolopyrimidine benzylidene 10 and acetamide 11, while the reaction of 8 with benzylidene derivatives yielded pyrimidopyrimidine 16 and 17.