A rapid, sensitive, and specific analytical method was developed and validated to quantify acamprosate calcium in beagle dog plasma. The method employs a single plasma protein precipitation, and the analytes are separated by chromatography on an Acquity UPLC HSS T3 column and analyzed by mass spectrometry in the multiple reaction monitoring (MRM) mode. The method has a chromatographic run time of 1.25 min and a linear calibration curve over the range 200-10000 ng/mL (r(2)>0.9994). The intra-day and inter-day accuracy and precision were within 10.0% for the analyte. Acamprosate was stable during all sample storage, preparation, and analytical periods. This method was employed in a pharmacokinetic study of an acamprosate 333 mg enteric-coated tablet in 8 male beagle dogs that received single 666 mg doses (333 mg x 2 tablets). The proposed method enables identification and quantification in pharmacokinetic studies of acamprosate in beagle dog plasma.

Fires are accidents that can cause numerous human casualties in multiplexes. The simple sprinkler systems applied in South Korea employ sprinklers to protect people against residential fires, as specified by the National Fire Protection Association (NFPA) standard 13D. Therefore, it is necessary to evaluate the fire control performance of multiplexes, which are at a greater risk than residential facilities. This study aims to verify the fire control performance of simple sprinklers in multiplexes and to develop a fire source that can be used as a protocol for testing fire suppression methods. The fire source was evaluated by using a 3 MW large-scale calorimeter (ISO 13784). The proposed fire source for multiplexes was applied in various forms according to the application methods, with ignition sources including cotton wick, wood crib, and heptane, and then the fire tests were conducted.

No abstract

In this study, to determine whether it is possible to apply Polyethylene (PE) compound pipe, which was developed to solve the problem caused by the corrosion of the fire protection piping currently in usein water based fire extinguishing systems, we performed an actual mockup fire test. Since no test standard was available related to the developed compound pipe, we compared and analyzed domestic and international technical materials and test standards and selected suitable fire test standards to evaluate the performance of the PE compound pipe. we applied two fire test standards to the PE compound pipe, viz. those for CPVC and metallic pipes, and conducted a total of 6 experiments to evaluate its performance. According to the results of the first and second fire tests based on the test standard for the CPVC pipe, neither the fitting nor the piping was damaged or deformed and no leakage was observed in the pressure test, which was performed for 5 minutes. For the fire test based on the metallic pipe test standard, a total of 4 experiments were conducted. The first two experiments were conducted to simulate the wet piping system. In the results of this fire test, neither leakage nor rupture was observed from the PE compound pipe and no damage was caused, such as the secession of the PE material. However, in the next two experiments, which simulated the dry system, the PE compound pipe suffered damage and rupture, including deformation before the fire fighting water was discharged. Therefore, we found that the piping performance of the PE compound pipe did not undergo any deterioration, including fusion, deformation, or damage, in the wet piping system simulated fire test.

This study was carried out to find optimal rice varieties and selection index for sushi. The suitability tests about appearance and palatability were conducted by 31 professional sushi chefs and the physicochemical and pasting properties of the selected 7 rice varieties (Koshihikari, Dami, Deuraechan, Boramchan, Juanbyeo, Sindongjin and Hopum) of milled and cooked rice were evaluated. According to the adaptability for sushi shape and taste of rice, Hopum and Sindongjin showed more suitable appearance and taste than others. Also, they showed remarkable pasting properties similar to Koshihikari which is widely known as a suitable for sushi. In the relationship between suitability and pasting properties for sushi, peak viscosity and breakdown viscosity showed highly positive correlation, and setback viscosity showed negative correlation. These results suggest that pasting properties can be applied to select the suitable varieties for sushi.