Highlights d Phenothiazine analog iHAP1 activates PP2A-B56ε and potently kills malignant cells d iHAP1 does not inhibit dopamine signaling or cause prohibitive neurologic toxicity d PP2A-B56ε dephosphorylates MYBL2-Ser241, causing prometaphase arrest with apoptosis d Other PP2A activators, SMAPs, activate PP2A-B55a and target different substrates

Mixed transition-metal oxides have witnessed increasing attention in catalysts and electrocatalysts. Herein, reduced graphene oxide-wrapped ZnMn2O4 microspheres (ZnMn2O4@rGO) were facilely synthesized through the solvothermal technique. The microstructure and morphology of ZnMn2O4@rGO microspheres were analyzed under Raman, X-ray photoelectron, X-ray diffraction, and energy-dispersive spectroscopies and scanning electron microscopy. The synthesized ZnMn2O4@rGO was employed as an excellent electrocatalyst for the reduction of hydrogen peroxide (H2O2). The ZnMn2O4@rGO-modified glassy carbon electrode (ZnMn2O4@rGO/GCE) exhibited a linear detection to H2O2 in a wide concentration range of 0.03–6000 μM with a detection limit of 0.012 μM. The biosensor was evaluated to determine H2O2 secreted by human breast cancer cells (MCF-7), indicating its promising applications in physiology and diagnosis.

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Fluorescence and phosphorescence are knowna s two kinds of fundamental optical signals,which have been used for myriad applications.T od ate,s imultaneous activation of stable fluorescence and long-lived room-temperature phosphorescence (RTP) emission in the aqueous phase remains ab ig challenge.W ep repare zinc-doped silica nanospheres (Zn@SiNSs) with fluorescence and RTPp roperties using af acile hydrothermal synthetic strategy.F or the as-prepared Zn@SiNSs,the recombination of electrons and holes in defects and defect-stabilized excitons derived from oxygen vacancy/ C = Nb onds lead to the production of stable fluorescence and long-lived RTP( emission lasting for % 9s ,q uantum yield (QY): % 33.6 %, RTPl ifetime: % 236 ms). The internal SiÀO bonded networks and hydrophilic surface in Zn@SiNSs can reduce nonradiative decayt of orm self-protective RTP,a nd also provideh igh water solubility,e xcellent pH-and photostability.

This study examines the adsorption behavior of methylene blue (MB) from aqueous solutions onto chemically activated halloysite nanotubes. Adsorption of MB depends greatly on the adsorbent dose, pH, initial concentration, temperature and contact time. The Langmuir and Freundlich models were applied to describe the equilibrium isotherms and the Langmuir model agrees very well with experimental data. The maximum adsorption capacities for MB ranged from 91.32 to 103.63 mg·g −1 between 298 and 318 K. A comparison of kinetic models applied to the adsorption data was evaluated for pseudo-first-order, pseudo-second-order, Elovich and intra-particle diffusion equation. The results showed the adsorption process was well described by the pseudo-second-order and intra-particle diffusion mode. Thermodynamic parameters suggest that the adsorption is spontaneous and endothermic. The obtained results indicated that the product had the potential to be utilized as low-cost and effective alternative for dye removal in wastewater.