Obesity is associated with an accelerated aging process, which prevents healthy aging. Both obesity and aging were manifested in the peroxisome proliferator-activated receptor-γ coactivator α (PGC-1α) level. These studies fulfill the scientific gap in assembled pharmacological activity assay of Caulerpa racemosa done in a previous preclinical trial. Six major compounds from sea grape (C. racemosa) extract were evaluated using an in silico approach against human pancreatic lipase, a-glucosidase, and a-amylase to predict prospective anti-obesity candidates. The lipase inhibitory activity of the extract reached 90.30 ± 0.40%, 1.75% lower than orlistat. The a-amylase inhibitory assay of the extract was 84.07 ± 5.28%, while the inhibitory activity against a-glucosidase was 81.67 ± 1.54%; both were lower than acarbose. We observe the effect of C. racemosa extract as anti-obesity with anti-aging by evaluating the obesity parameters in the human body for a 4-week period. There was a significant decrease in blood glucose, total cholesterol, low-density lipoprotein (LDL), triglycerides (TG), waist circumference, waist-hip ratio, and body weight (p < 0.05); PGC-1α and high-density lipoprotein (HDL) increased significantly (p = 0.000), in Group B when compared with Group A. Our study revealed that sea grape extract is a potent anti-obesity with an anti-aging reagent that does not produce any significant adverse effects.

This is observational-analysis study with quantitative measurement and cross-sectional method. The following attributes were chosen by a preselection of 26 randomly selected patients: cost of the products, travel time, experience of the aesthetic physician, method of referral, and easy to communicate / to consult. The study shows that the two most important attributes are easy to communicate / to consult and experience of the aesthetic physician. Another attributes are travel time, method of referral, and cost of the products. Conjoint analysis may help to determine client�s preferences. It also shows which levels positively or negatively contribute in every attribute.

Fitness centre Health and Sport Clinic (HSC) Universitas Negeri Yogyakarta (UNY) merupakan salah satu pusat kebugaran berbasis sport science yang dukung dengan sarana, prasarana, dan sumber daya manusia yang berkompetensi, sehingga menjadi salah satu pionir pusat kebugaran di Yogyakarta. Beberapa tahun belakangan banyak bermunculan pusat kebugaran baru yang menjadikan pesaing bagi fitness center HSC UNY. Fitness center HSC UNY akan mampu bertahan dan mengungguli pesaingnya dengan salah satu jalan, yaitu mengidentifikasi permintaan pasar yang dilakukan dengan cara melihat preferensi members dalam memilih sebuah fitness center. Penelitian ini bertujuan untuk mengetahui preferensi members dalam memilih fitness centre HSC UNY. Penelitian ini menggunakan metode konjoin dengan populasi seluruh members fitness center HSC UNY yang kemudian dipilih sebanyak 96 members dengan teknik cross-sectional untuk menjadi responden penelitian. Instrument yang digunakan pada penelitian ini, yaitu angket atau kuesioner untuk memperoleh data. Data yang sudah diperoleh dianalisis menggunakan teknik analisis data kuantitatif. Hasil penelitian ini menunjukkan bahwa faktor members memilih fitness center HSC UNY berdasarkan (1) harga atau biaya members sebesar 36,3%, (2) konsultasi sebesar 24,7%, (3) waktu tempuh sebesar 16,9%, (4) pemberi referensi sebesar 14,7%, dan (5) pengalaman PT sebesar 7,3%. Harga atau biaya menjadi faktor yang paling mempengaruhi keputusan members dalam memilih fitness center HSC UNY. Faktor berikutnya yang turut mempengaruhi, yaitu kemudahan konsultasi, waktu yang ditempuh, pemberi referensi, dan pengalaman personal trainer.Identification of member's preferences fitness center health and sports clinic Yogyakarta State University AbstractFitness center Health and Sport Clinic (HSC) Yogyakarta State University (UNY) is one of the sports science-based fitness centers that is supported by facilities, infrastructure, and competent human resources, thus becoming one of the pioneers of fitness centers in Yogyakarta. In recent years, many new fitness centers have emerged that are competitors for the HSC UNY fitness center. The UNY HSC fitness center will be able to survive and outperform its competitors in one way, namely identifying market demand by looking at members' preferences in choosing a fitness center. This study aims to determine the preferences of members in choosing the HSC UNY fitness center. This study used the conjoint method with a population of all members of the UNY HSC fitness center which was then selected as many as 96 members with a cross-sectional technique to become research respondents. The instrument used in this study, namely a questionnaire or questionnaire to obtain data. The data that has been obtained were analyzed using quantitative data analysis techniques. The results of this study indicate that the members choose the HSC UNY fitness center based on (1) member prices or fees of 36.3%, (2) consultation by 24.7%, (3) travel time by 16.9%, (4) referrals by 14.7%, and (5) PT experience by 7.3%. Price or cost is the most influencing factor in members' decisions in choosing the HSC UNY fitness center. The next factor that also influences is the ease of consultation, the time taken, the reference provider, and the experience of the personal trainer

Background: Developing countries need funding for researchers to maximize the evidence base, especially in stunting research. This short policy is expected to provide opportunities for Indonesia to receive more research funding to stunt philanthropists. Policy and implications: Multi-sector cooperation is arguably the leading player in acceleration programs to reduce growth delays. The Stunted Reduction Acceleration Program, complemented by higher research and development expenditures (RDEs) and open policies to support philanthropic activities in Indonesia, will help improve the efficiency of stunted stunt reduction through adequate funding and investment. As evidenced by Singapore and Thailand, the increase in government budgets focused on research and development (R&D) and supportive environments, as shown by Global Philanthropy Environment Index (GPEI), prove that evidence-based and practical researches can lead to the reduction of estimated prevalence of stunting rather than innovation-stage research. Recommendations: Attention needs to be directed in proposing major changes in law and policy which regulate the allocation of research-development expenditure, which will initiate the creation of a supportive environment for philanthropy acts regarding stunting. The challenges associated with these issues are: (1) Stunted research and innovation are still left behind, (2) The availability of data and the lack of transparency, (3) Subpar performance in relation to philanthropists, (4) Inconsistent legal definitions and a lack of industry-specific guidelines, (5) Inadequate law enforcement, (6) Local leaders must engage in evidence-based advocacy, (7) Philanthropists have limited opportunities to learn.

Indonesia faced one of the most tragic and challenging health problems at the beginning of 2018, many children in Papua's Asmat Regency were suffering from malnutrition and measles. More than a thousand children were treated while 78 children under five years of age have died, mostly indigenous children. Asmat Regency is located in Indonesia's easternmost province with poor infrastructure and communication networks, also high transportation costs due to swampy regions criss-crossed by rivers, hard-to-reach from the center to the districts. Asmat's belief in their ancestors has formed their way of life and shaped their behavior, choices, and attitudes towards health issues, such as poor awareness regarding the fulfillment of daily nutritional intake, which is potentially harmful. Curative care is the highest priority in an extraordinary incident such as an outbreak or a mass-casualty disaster. However, establishment of the cultural hegemony of biomedicine will not be achieved overnight. Changing people's health behavior is a significant challenge. To maintain health sustainability, we must reach the entire community, including rural and remote areas, and work together with local indigenous stakeholders to bridge the gaps in sociocultural understanding. Resources that enhance the quality of life can have a significant influence on population health outcomes. By applying what we know about the Social Determinants of Health (SDH), we may not only improve population health but also advance health equity. The author offers a participant observation, discussing the social determinants based on self-experience living in an indigenous community in Asmat. This article aims to provide an overview of SDH in Asmat through the approach of medical anthropology, as the SDH may potentially have roles in health outbreaks, especially in the case of malnutrition and measles in early 2018.