Multinucleate cells are characteristic, but neither exclusive nor pathognomonic, of multinucleate cell angiohistiocytoma, since they can also appear in other inflammatory, neoplastic, or reactive processes. The presence of these cells and vascular proliferation in dermis media are the principal histopathological findings in this infrequent entity. In immunohistochemical studies, the multinucleate cells are often positive for vimentin and factor XIIIa.

No abstract

An 87-year-old woman developed erythema, induration and tenderness of the skin overlying each breast. One year before, she had undergone an axillary lymph node dissection because of metastases from melanoma. The primary site was unknown. A skin biopsy showed pigmented tumor nests within the dermal lymphatic vessels, and immunohistochemistry confirmed the melanocytic origin. The diagnosis of inflammatory metastatic melanoma was made.

A case of pancreatic mucinous cystadenocarcinoma (PMC) with two pseudosarcomatous mural nodules (PMN) is described. These nodules have not been previously described in this type of tumor. In ovarian mucinous tumors (OMT), similar nodules have been reported, the nature of which has been discussed in detail. Here the similarity between the tumor described here and ovarian tumors is stressed. The immunohistochemical study carried out disclosed in the nodules strong positive staining for vimentin and moderate positivity for keratin and epithelial membrane antigen. These findings, along with histologic details, favor the epithelial nature of the nodules. It was concluded that the nodules are foci of anaplastic carcinoma with high proliferative cell rate, which could explain the coexpression of vimentin and keratin. Cancer 67:494-498,1991. HE PANCREATIC MUCINOUS cystadenocarcinoma T (PMC) is very uncommon, representing only from1% to 2% of all malignancies in this organ.' We will present a case of PMC with pseudosarcomatous mural nodules (PMN), a finding which, to the best of our knowledge, was not previously published in this location. Mural nodules of similar histologic appearance have been reported in ovarian mucinous tumors (OMT), and their nature and significance in the prognosis is still in dispute.*-'In our case, the histologic picture and the immunohistochemical findings favored the interpretation that the sarcoma-like nodules represented areas of poorly differenciated carcinoma. Case ReportA 45-year-old woman underwent surgery in another hospital 2 years before admission to our hospital due to a pseudopancreatic cyst, the exact nature of which could not be confirmed.

No abstract