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The penalty of write operations is one of the main hindrances for adopting nonvolatile memory for IoT devices. As a solution for mitigating this problem, the read-before-write scheme is proposed to prevent unnecessary writing by comparing all bits to be written with the existing values. However, this approach also generates additional read accesses for every write access. To reduce these read operations, we design a zero-bit pattern scheme that deactivates bit cells indicated as zero bits during access to the cache. In our experiments, the dynamic energy consumption is decreased by 35.0% with 2.3% additional storage.

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BackgroundSeveral studies have shown the cost-effectiveness of direct oral anticoagulants (DOACs), compared with warfarin, to prevent atrial fibrillation (AF) related complications. However, few have reported cost-effectiveness of DOACs in AF patients with intermediate stroke risk. Thus, we investigated the cost-effectiveness of DOACs vs. warfarin in non-valvular AF patients with intermediate stroke risk using national representative data.MethodsWe identified 7,954 newly diagnosed non-valvular AF patients (≥18 years) with intermediate stroke risk (CHA2DS2-VASc score: 1 for men and 2 for women) using the national healthcare utilization data from August 1, 2016, to July 31, 2019. Annual incidence rate of AF-related composite outcomes (heat failure, myocardial infarction, ischemic stroke, intracerebral hemorrhage, and gastrointestinal bleeding) was estimated. Cost-effectiveness was estimated using a Markov chain model with the transition probability of 1 year. The willingness-to-pay (WTP) was set at $32,000 per quality-adjusted life-year (QALY) gained.ResultsThe total cost of warfarin, rivaroxaban, apixaban, dabigatran and edoxaban was $2,874, $5,761, $5,151, $5,761 and $5,851, respectively. The QALYs gained were 10.83, 10.95, 11.10, 10.49 and 10.99 years, respectively. The incremental cost-effectiveness ratio of rivaroxaban, apixaban, dabigatran and edoxaban was $29,743.99, $8,426.71, -$8,483.04 and $18,483.55, respectively. The WTP was set at $32,000. DOACs (except dabigatran) were more cost-effective compared with warfarin because they did not exceed the WTP in the base-case analysis.ConclusionOur findings showed that DOACs were more cost-effective than warfarin in non-valvular AF patients with intermediate stroke risk.

In this letter, we propose a novel wear leveling technique we call Hidden cold block-aware Wear Leveling (HaWL) using a bit-set threshold. HaWL prolongs the lifetime of flash memory devices by using a bit array table in wear leveling. The bit array table saves the histories of block erasures for a period and distinguishes cold blocks from all blocks. In addition, HaWL can reduce the size of the bit array table by using a one-tomany mode, where one bit is related to many blocks. Moreover, to prevent degradation of wear leveling in the one-to-many mode, HaWL uses bit-set threshold (BST) and increases the accuracy of the cold block information. The performance results illustrate that HaWL prolongs the lifetime of flash memory by up to 48% compared with previous wear leveling techniques in our experiments.