Platelet indices, MPV and PDW, can be used for the determination of disease severity, and lead to therapeutic strategies for PE patients.

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PURPOSE: To investigate the possible protective effect of thymoquinone (TQ) in cisplatin (CP) induced myocardial injury. METHODS:A total of 28 adult male Wistar-Albino rats were randomly and equally divided into four groups as follows: Group 1 (control), Group 2 (CP at 15 mg/kg dose), Group 3 (TQ 40 mg/kg/day for two days prior to CP injection and on third day, CP at 15 mg/kg dose was intraperitoneally administered and TQ treatment continued until fifth day) and Group 4 (TQ at 40mg/kg/day dose for five days). RESULTS:There was a significant increment in CP group in terms of congestion, edema and pycnotic nuclei in myocardial fibers, comparing with other groups. TQ group exhibited significant increase in expression of antiapoptotic protein Bcl-2, comparing with CP group (p<0.05). In only CP administered group, expression of antiapoptotic protein Bcl-2 was lowest comparing with other groups. CONCLUSION:Established data indicate that cisplatin is cardiotoxic and thymoquinone may be useful in treating CP-induced cardiac injury.

ally drain into the innominate vein, the thymus can be easily separated from the pericardium and rotated upward to serve as a vascularized pedicle flap. The flap can separate the tracheostomy from the jeopardized substernal space. Thoracic transposition of the omentum flap could also be used to treat DSWI [5], but this would entail the additional trauma of a laparotomy. Our technique is relatively simple, and did not cause additional morbidity. The limitation of this technique may be its use in patients with a very atrophic thymus, in whom other techniques should be considered. In summary, we describe a case where a thymus pedicle flap could be used to eliminate contamination of airway bacteria in a patient with DSWI related to the tracheostomy. References

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