Objective: The objective of our research is to prepare silver nanoparticles from the rhizome extract of Curcuma caesia and develop topical herbal gel formulation for the effective treatment of acne. Methods: In this present study, silver nanoparticles were synthesized using hydroalcoholic extract of Curcuma caesia rhizome. Silver nanoparticles loaded gels were evaluated for pH, viscosity, spreadability, in vitro release, estimation of total flavonoids and alkaloid content and antibacterial (propioni bacterium acne) studies. Results: The synthesized silver nanoparticles were stable, spherical shape with average particle size of 220.5 nm. The results obtained in the developed formulation showed no lumps, had uniform color dispersion and were free from any fiber and particle. It was also observed to have easy washablity, good spreadability, pH was found to be 6.58±0.02 and 7.02±0.01 similar to pH of the skin. The antibacterial study of the developed formulation showed inhibitory activity against Propioni bacterium acne. Synthesized silver nanoparticle loaded gel displayed drug release of optimized formulation F3 follows the Higuchi kinetic model, and the mechanism is found to be non Fickian/anomalous according to Korsmeyer–Peppas. Silver nanoparticles effectively inhibited the growth of both microorganism indicating good antibacterial properties. Conclusion: Synthesis of silver nanoparticles using Curcuma caesia is a new, green method and not reported yet, as per literature survey done for this project. Successful synthesis and evaluation of silver nanoparticles was proved by the in-vitro study. Keywords: Curcuma caesia, Silver nanoparticles, Propioni bacterium acne, Acne, Flavonoids content, Alkaloid content, Antibacterial.

Background The ability to inhibit oxidative stress has been established as the prime mechanism in treatment of several disease conditions. In view of this, two new series of coumarin–chalcone hybrid molecules (5a–o and 6a–o) were synthesized using various aromatic aldehydes. The structures of the compounds were confirmed using IR, 1HNMR and mass spectral analyses. The compounds were evaluated for their antioxidant potential against 2,2-diphenyl-1-picrylhydrazyl (DPPH) and hydroxyl radicals in scavenging assays. Results Compounds 5o and 5k exhibited significant antioxidant potential as compared to the standard drug (ascorbic acid). Conclusions It can be concluded that the coumarin–chalcone treatment have the potential to be optimized further to generate scaffolds capable to treat many pathological conditions.

Cancer can conquer or feast on nearly all portions of the body. The cumulative illness and high humanity of cancer generate an innumerable claims for the expansion of innovative anticancer drugs. Coumarin (known as 1,2-benzopyrone or o-hydroxycinnamic acid-8-lactone) encompasses a huge class of phenolic offshoots that originate in plants and they are entailed of bonded benzene and a-pyrone rings. Numerous studies have exposed that several substituents on the coumarin essential structure stimulus different biological activities. Coumarin advert a character of pathways in cancer like kinase inhibition, cell cycle annexation, angiogenesis inhibition, telomerase inhibition, antimitotic activity, carbonic anhydrase inhibition, monocarboxylate transporters inhibition, aromatase inhibition, and sulfatase inhibition. Coumarin moiety is a beneficial template for the progress of novel anticancer agents.

Herbal medicine and their preparations have been widely used from the thousands of years in developing and developed countries in the primary health care of society and community. Quality control is one of the very important and essential steps in the manufacturing of herbal preparations as quality of product affects the safety and efficacy of medicines. Quality control is mainly applied for both raw materials along with excipients used and finished product. Flavonoids are the class of polyphenolic compounds, which are mainly distributed throughout the plant kingdom. Quercetin is a flavonoid which shows major pharmacological activities like anticancer, hepatoprotective activity, anti-spasmodic, and anti-inflammatory activity. In present investigation qualitatively and quantitatively estimation of the extracts of Curcuma amada has been carried out.

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