In the current study, the synthesis of tetra-4-(2-methoxyphenoxy) carboxamide cobalt(II) amide-bridged phthalocyanine (CoTMePhCAPc) is described, as well as its characterization by Fourier transform infrared (FT-IR), UV–visible, and mass spectroscopy; powder X-ray diffraction (PXRD); thermogravimetric analysis (TGA); scanning electron microscopy (SEM); and electrochemistry. Sensing of nitrite (NO2 –) and hydrogen peroxide (H2O2) simultaneously was done on CoTMePhCAPc with the composite multiwalled carbon nanotube (MWCNT)-modified glassy carbon electrode (CoTMePhCAPc/MWCNT/GCE) in the range of linear absorption (NO2 – and H2O2: CV 50–750, differential pulse voltammetry (DPV) 50–750, CA 50–500 nmol L–1), lower detection limit (NO2 – and H2O2: CV 10.5 and 12.5, DPV 10.5 and 11.2, CA 6.0 and 5.5 nmol L–1), and sensitivity (NO2 – and H2O2: CV 0.379 and 0.529, DPV 0.043 and 0.049, CA 0.033 and 0.040 μA nM–1 cm–2). The composite electrode exhibits improved electrocatalytic behavior compared to modified electrodes for nitrite and H2O2. The CoTMePhCAPc/MWCNT/GCE sensor displays good selectivity even in the presence of an excess of interfering metal ions and biomolecules at the applied potentials of +400 mV (nitrite) and −400 mV (H2O2). Moreover, the fabricated sensor was studied with various phosphate-buffered saline (PBS) (pH 5–9) electrolyte solutions. The unknown H2O2 concentration in blood samples and apple juice and nitrite concentration in drinking water and butter leaf lettuce were all measured using the usual addition method. Docking analysis clearly indicates that the ligand shows excellent inhibition activity toward the three subjected protein molecules.

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The synthesis of Schiff base transition metal complexes always appears to be fascinating because of the possibility of obtaining coordination compounds of unusual structure and stability. These compounds possess special attention in the field of pharmaceuticals because of their wide spectrum of biological applications. Schiff base complexes form versatile compounds which actively take part in metalloenzymes and also can act as biomimetic models because of their closeness to natural proteins and enzymes. Hence, the present paper mainly aims in the synthesis of Schiff base ligand by modifying the functional group of the drug, diclofenac and using that Schiff base ligand four novel metal complexes of Cu(II), Co(II), Ni(II), and Zn(II) were prepared. The nature of bonding and the stereochemistry of the metal complexes can be deduced from elemental analyses, molar conductance, magnetic susceptibility, IR, electronic, 1 H NMR and Mass. The analytical data reveals that the metal to ligand ratio is 1:2. Due to lower molar conductivity values, the metal complexes are considered nonelectrolytes. The spectral analysis data describes that all the metal complexes possess octahedral geometry. The drug diclofenac synthesized Schiff base ligand and novel metal complexes were subjected to antimicrobial as well as anti-inflammatory activities. The Schiff base ligand and metal complexes show promising biological activities.

Benzofurans display a wide array of pharmaceutical activities. The present work incorporates the synthesis of some novel benzofuran derivatives. The compound 1 (z)-3-amino-7methoxy-N1-(2-oxoindolin-3-yliedene)benzofuran-2-carbohydrazide was synthesized by refluxing carbohydrazide and isatin. The compound 1 formed the key intermediate for the synthesis of compounds 2a-c. The structures of prepared derivatives were established by physical and spectral methods such as elemental analysis, FTIR, 1HNMR and Mass. The molecular docking studies was performed to detect the behavior of compounds towards target proteins. The derivatives were further screened for antibacterial and antifungal analysis.