Vaginal lactobacilli influenced colonization with C. difficile, and Candida. Vaginal flora is a potent factor influencing the development of bacterial flora in the neonatal and infantile gut. The extension of the observation period until 3 months of life allow to discover the potential changes in the intestinal flora of children.

Our results may indicate that lactobacilli in maternal vagina influence the development of neonatal immune system. Yet, more research is needed using specified bacterial antigens.

CD30 was initially described as Ki-1 Ag on Reed-Sternberg cells of Hodgkin's lymphoma and its and CD30L(+) expression on T cells in placenta were equally frequent in the atopic and non-atopic women. In this article we present a study of CD30 mean fluorescence intensity (MFI) on CB T CD4(+) cells. We tested the hypothesis that in newborns with atopy family history there is a changed CB T cells response after antigen stimulation comparing with those without atopy family history. The study population consisted of 31 newborn babies (29-breastfed, two non-breastfed) and their mothers. Eleven of them had positive and 20 had negative atopy family history. Performed tests included cord blood, which was a subject to flowcytometry analysis and was cultured for 24 h, cytokine production was measured (IFN- gamma, IL-4 and IL-12). Secondly, we measured total maternal and cord blood IgE levels. We studied CD30 MFI as in our studies in larger group of newborns, CD30 expression on CD4(+) T cells appeared to be very low. MFI of CD4(+) CD30(+) after PHA-stimulation (213.55: range: 41.77-434.51) was significantly increased compared to MFI of CD4(+) CD30(+) before PHA-stimulation (43.63: range 28.67-134.67)(p 0.05). After PHA stimulation MFI of CD4(+) CD30(+) in non-atopic (273.05 (range: 42.9-434.51) was significantly increased compared with the atopic newborns to MFI of 87.1 (range: 41.78-241.42) (p = 0.00). We have not found any correlation between MFI of CD4(+) CD30(+) and total maternal and total CB IgE levels. The role of CD30 in immunological response needs further research studies.

No abstract

Introduction: Flat feet is one of the most common posture defects among children and it usually co-occurs with valgus of the heels, which is called pes plano-valgus. There are many diagnostic methods and physiotherapeutic activities that allow for early detection and appropriate correction of the defect. The use of non-surgical methods may allow the child to avoid surgery in the future. Aim and Methods: Review and analysis of the current scientific literature on the diagnosis and physiotherapy of plano-valgus feet in children. Conclusions: In the diagnostic process, there are many static and dynamic methods for the assessment of plano-valgus foot among children. Special devices such as plantoconturograph, podoscope, and pedobarographic mat are used in the diagnosis of feet in children and have proven to be helpful in the detailed analysis of foot defects. However, an extensive range of physiotherapeutic methods allows for comprehensive treatment using not only corrective exercises, but also physical therapy treatments in order to relieve pain and accelerate recovery. Orthopedic appliances, such as supination insoles, also play an important role in the treatment. The best results were seen in the use of comprehensive treatment and multiple terapeutic methods. Early detection and correct diagnosis of foot abnormalities allow for appropriate treatment with the use of a wide range of physiotherapy methods. This increases the chances of restoring normal foot functions among children and reducing pain with other abnormal symptoms.