Coix lacryma-jobi (Hanjeli) is known to posses anti-microbial properties. Therefore, phytochemical compounds of C. lacryma-jobi have been studied to produce novel antimicrobial agents as treatments against antibiotic-resistant bacteria.The objective of this study was to determine the phytochemical composition and antibacterial activity of the C. lacryma-jobi oil against Escherichia coli, Staphylococcus aureus, and Bacillus subtilis. The phytochemical composition of the oil was determined via gas chromatography mass spectrophotometry (GC-MS). Moreover, agar disk and agar well diffusion were employed to screen the antibacterial activity of the oil. An agar well diffusion test was implemented to determinate MIC's (minimum inhibitory concentrations). Dodecanoic acid, tetradecanoic acid, 2,3-dihydroxypropylester, 1,3-dioctanoin, N-methoxy-N-methyl-3,4-dihydro-2H-thiopyran-6-carboxamide, propanamide, 5-Amino-1-(quinolin-8-yl)-1,2,3triazole-4-carboxamide, and pyridine were identified in the C. lacryma-jobi oil. The MIC value of the oil was 0.031 g/L and the MBC of the oil was 0.125 g/L effective in all test bacteria. Dodecanoic acid displayed inhibitory activity against gram-positive and gram-negative bacteria. Therefore, our research demonstrated C. lacryma-jobi (Hanjeli) oil exhibited antibacterial activity against E. coli, S. aureus, and B. subtilis. These research suggest that C. lacryma-jobi root oil could be used for medicinal purposes; however clinical and in vivo tests must be performed to evaluate its potential as an antibacterial agent.

is an ongoing pandemic as we speak in 2022. This infectious disease is caused by the SARS-CoV-2 virus, which infects cells by binding to the angiotensinconverting enzyme 2 (ACE2) receptor on the cell surface. Thus, strategies that inhibit the binding of SARS-CoV-2 to the ACE2 receptor can stop this contagion. Hanjeli (Coix lacryma-jobi) essential oil contains many bioactive compounds, including dodecanoic acid; tetradecanoic acid; 7-Amino-8imino-2-(2-imino-2H-chromen-3-yl); and 1,5,7,10-tetraazaphen-9-one. These compounds suppress viral replication and may prevent Covid-19. Accordingly, this study assessed whether, these four limonoid compounds can block the ACE2 receptor. To this end, their physicochemical properties were predicted using Lipinski's "rule of five" on the SwissADME website, and their toxicity was assessed using the online tools ProTox and pkCSM. Additionally, their interactions with the ACE2 receptor were predicted via molecular docking using Autodock Vina. All the four compounds satisfied the "rule of five" and tetradecanoic acid was predicted to have a higher affinity than the comparison compound remdesivir and the original ligand of ACE2. Molecular docking results suggested that the compounds from hanjeli essential oil interact with the active site of the ACE2 receptor similarly as the original ligand and remdesivir. In conclusion, hanjeli essential oil contains compounds predicted hinder the interaction of SARS-CoV-2 with the ACE2 receptor. Accordingly, our data may facilitate the development of a phytomedical strategy against SARS-CoV-2 infection.

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Tujuan kegiatan pengabdian ini adalah  sosialisasi tentang daur ulang limbah organik menjadi ekoenzim  untuk menjaring data tentang kepedulian masyarakat terhadap limbah organik dan kebermanfaatan ekoenzim di kalangan masyarakat. Metode yang dilakukan adalah sosialisasi tatap muka, paparan secara online dan diskusi grup komunitas di media sosial.  Jumlah mitra yang terlibat 21 orang wanita dari kelompok PKK (Pemberdayaan Kesejahteraan Keluarga) di Desa Giri Mekar, Ujung Berung, Bandung. Pada kegiatan sosialisasi tersebut para peserta melakukan praktek membuat ekoenzim. Sedangkan penyampaian paparan secara online dan media sosial dilakukan untuk mencapai target responden dari generasi muda dan masyarakat umum dengan jumlah peserta lebih banyak (524 responden).  Responden terdiri dari 82,3% wanita dan 17,7% pria. Angket penjaringan data menunjukkan bahwa masyarakat mengetahui tentang limbah organik (92,4%), ekoenzim (52,9%); kebermanfaatan ekoenzim untuk pupuk (64,1%); dan untuk lain-lain (44,8%). Hasil ini menunjukkan bahwa masih ada masyarakat yang belum melakukan daur ulang sampah organic menjadi ekoenzim. Walaupun sosialisasi ekoenzim terus dilakukan oleh para relawan melalui beberapa metoda. Promoting Ecoenzymes Based on Organic Waste to Increase Awareness in Protecting the Environment The purpose of this service activity is to socialize about recycling organic waste into eco enzymes to collect data about public awareness of organic waste and the benefits of eco enzymes among the community. The methods used are face-to-face socialization, online exposure, and community group discussions on social media. The number of partners involved was 21 women from the PKK (Family Welfare Empowerment) group in Giri Mekar Village, Ujung Berung, Bandung. In the socialization activity, the participants practiced making eco enzymes. Its use online and social media is carried out to reach the target respondents from the younger generation and the general public with a larger number of participants (524 respondents). Respondents consisted of 82.3% women and 17.7% men. The survey data shows that the public knows about organic waste (92.4%), eco enzymes (52.9%); the usefulness of eco enzymes for fertilizers (64.1%); and for others (44.8%). These results indicate that there are still people who have not recycled organic waste into eco enzymes. Although the socialization of eco enzymes continues to be carried out by volunteers in several ways.

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