No abstract

Background: A growing body of evidence links psoriasis to several metabolic disorders, but the causal relationship between psoriasis and nonalcoholic fatty liver disease (NAFLD) remains understudied. Purpose: To measure the correlation between the severity of psoriasis and the degree of NAFLD. Patients and Methods: A cross-sectional study was conducted on adult patients with psoriasis in the Dermatovenereology Outpatient Clinic of Cipto Mangunkusumo Hospital from December 2017 through February 2018. Psoriasis severity (psoriasis area and severity index [PASI] and body surface area [BSA]) was recorded and compared with NAFLD degree measured by controlled attenuation parameter (CAP). Results: A total of 36 subjects were enrolled with an average age of 49.08 years (±15.52 years). The proportions of mild, moderate, and severe psoriasis were 50%, 27.8%, and 22.2%, respectively. Median of PASI was 6.1 (2-38.4) and BSA was 7.5 (2-93). The proportion of NAFLD was 77.8%. The mean of the CAP score was 250.03±45.64. There was no statistically significant correlation between psoriasis severity based on PASI and CAP score (r = 0.258; p = 0.128). However, if the degree of psoriasis was based on BSA, a significant correlation was found (r = 0.382; p = 0.021). The body mass index (BMI) and abdominal circumference were significantly correlated with CAP score (r = 0.448, p = 0.006 and r = 0.485, p = 0.003, respectively). Conclusion: Psoriasis extension correlates with NAFLD severity; further studies should assess in detail the effect of therapies on this pathophysiological link.

Purpose Repeated exposure to ultraviolet light is the most significant factor that contributes to photoaging. Dermoscopy photoaging scale (DPAS) is a noninvasive examination utilized for the diagnosis of photoaging. However, there has been no study analyzing the correlation between DPAS and sun index. Hence, this study aims to find out the dermoscopic features of photoaging and its association with sun index score in the coastal population. Patients and Methods This was a descriptive cross-sectional study on individuals living in Cilincing, a coastal area, at North Jakarta. Healthy male or female subjects aged over 18 years old with sun exposure equal or more than 2 hours daily were recruited consecutively. History taking was performed to document the sociodemographic characteristics (age, gender, skin type, smoking habit) and sun index score. Physical examination and dermoscopic examination were conducted to determine DPAS score. Associations of DPAS and photoaging profiles were analyzed with Chi-squared test while correlation between DPAS score and sun index was analyzed with Pearson correlation test. Results A total of 100 subjects were included in this study. The median DPAS of the subjects was 9 (1–21). Right cheek had the highest median DPAS of 3 (0–6), followed by the left cheek with median DPAS of 3 (0–7). Men had a higher median DPAS score than women (9 vs 8). There was a significant difference between DPAS score and age (p<0.001). There was no significant correlation between DPAS score and sun index (r = −0.005; p = 0.957). Conclusion Factors associated with high DPAS score were cheek predilection, male, actively smoking, Fitzpatrick skin type IV, and increasing age. DPAS score has no correlation with sun index.

Tingginya insiden keganasan kulit yang ditemukan pada stadium lanjut membutuhkan kemampuan lebih baik untuk mengenali tanda dan gejala awal. Pengenalan dini gejala klinis kanker kulit berpigmen, terutama melanoma maligna, dapat dengan pemeriksaan lesi menggunakan kriteria ABCDE. Kriteria ini sederhana dan mudah digunakan, baik oleh tenaga medis maupun masyarakat awam. Makin banyak kriteria ABCDE yang terpenuhi, makin tinggi kemungkinan suatu lesi adalah kanker kulit.   High incidence of skin malignancy found in advanced stages calls for a better clinical judgment to detect early signs and symptoms. Screening for early clinical findings of pigmented skin cancer, especially malignant melanoma, can use ABCDE criteria. The criteria are simple and easy to apply, either by medical professionals or general public. The more ABCDE criteria were met, the higher chance that a lesion is a skin cancer.