No abstract

No abstract

In 160 healthy subjects, 542 experiments were conducted to assess some behavioral and physiological effects of alcohol ingestion. Both subjective mood tests and objective performance tests were given and the results correlated with blood alcohol levels. Also analyzed were changes after interaction with CNS-active drugs, "hangover," adaptation, and tolerance.-TV NUMBER of studies in our laboratory have been devoted to the investigation of metabolism and action of alcohol in man under various conditions, ranging from studies on the influence of dose and type of beverage to the action of compounds affecting metabolism, CNS functions, or both, in moderate consumers as well as in heavy drinkers and alcoholic subjects.The main interest has been focused on possible effects of alcohol on the central nervous system in relation to changes in alcohol metabolism and blood levels.This aim has necessitated the design of experiments allowing the following of time-course of possible effects and their relation to blood alcohol and other parameters and the use and development of sensitive methods capable of measuring significant departures from alreadylow blood alcohol levels; and allowing the recording, evaluation, and storage of information in a form to make possible

No abstract