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A quantitative strategy towards the detection of sofosbuvir in human plasma was developed with online-SPE-LC-HRMS using t-MS2, t-SIM and F-SIM modes.

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We examined the tissue distribution and elimination of quinocetone (QCT) and its major metabolites 1‐desoxyquinocetone (1‐DQCT), di‐desoxyquinocetone (BDQCT), and 3‐methyl‐quinoxaline‐2‐carboxylic (MQCA) in ducks. The analytes were simultaneously quantitated using a UPLC‐MS/MS method after oral administration of QCT at 100 mg·kg−1 day−1 for 7 days. We found that QCT and its major metabolites were widely distributed in duck tissues. The concentrations indicated that the primary compound in the liver, kidney, and heart was MQCA and the primary compound in the stomach, intestine, spleen, and lung was QCT. We also identified that MQCA was the most appropriate compound for QCT residue monitoring. The liver and kidney are the primary QCT target organs in ducks, and this study provides clear monitoring tools and important data to evaluate its safety.

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