Non-drug varieties of Cannabis sativa L., collectively namely as "hemp", have been an interesting source of food, fiber, and medicine for thousands of years. The ever-increasing demand for vegetables oils has made it essential to characterize additional vegetable oil through innovative uses of its components. The lipid profile showed that linoleic (55%), α-linolenic (16%), and oleic (11%) were the most abundant fatty acids. A yield (1.84-1.92%) of unsaponifiable matter was obtained, and the most interesting compounds were β-sitosterol (1905.00 ± 59.27 mg/kg of oil), campesterol (505.69 ± 32.04 mg/kg of oil), phytol (167.59 ± 1.81 mg/kg of oil), cycloartenol (90.55 ± 3.44 mg/kg of oil), and γ-tocopherol (73.38 ± 2.86 mg/100 g of oil). This study is an interesting contribution for C. sativa L. consideration as a source of bioactive compounds contributing to novel research applications for hemp seed oil in the pharmaceutical, cosmetic food, and other non-food industries.

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Alzheimer's disease (AD) is the most common type of dementia. Recent studies have assessed the possibility of using statins as treatment for AD. However, their effi cacy is not clear. In this study, we collected the most relevant information about the effi cacy of statins for the treatment of AD. We conducted a systematic literature search using MEDLINE, EMBASE and The Cochrane Library. We included clinical trials, meta-analyses and systematic reviews that analysed the effi cacy of statins in AD. We also extracted the characteristics and effi cacy results of the studies selected. Of the 304 articles identifi ed, 13 complied with the inclusion criteria. The scientifi c quality of studies was high and their results indicated that there were no signifi cant differences in the main effi cacy variables between statins and placebo treatment for AD. Therefore, according to the available scientifi c evidence, statins have not shown an improvement in cognition and do not appear to offer signifi cant benefi ts to patients with AD. KEYWORDS :Alzheimer's disease , statins , effi cacy , systematic review IntroductionAlzheimer's disease (AD) is the most common type of dementia. It is a neurodegenerative pathology, whose incidence has increased in the past few years. With an estimated prevalence of 46.8 million cases worldwide in 2015, the number of patients with AD is expected to continue to increase in the coming years. 1There are two main manifestations of AD: early-onset AD, which especially affects young people, and late-onset AD, which is more common and occurs mainly in older people, usually patients over 65 years old; therefore, ageing is considered to be the main risk factor for the disease. 3 When these deposits accumulate in the cerebral cortex, they cause neurotoxic effects. Aβ peptides derive from the amyloid precursor protein (APP) in response to the activity of secretases (α-SAPP, β-SAPP and γ-SAPP), which cleave the APP into different fragments. 4 These secretases have been the subject of scientific research because of their role in the regulation of Aβ.

Anti-inflammatory effects on human monocytes by phenolic amides present in defatted hempseed fractions (Cannabis sativa L.).