Terpestacin, a new antibiotic which inhibits syncytium formation, was isolated from Arthrinium sp. FA1744(ATCC74132). The structure of terpestacin was elucidated as a bicyclic sesterterpene on the basis of spectroscopic data and chemical derivatization.

ABSTRACT. Streptococcus suis is an important pathogen for both swine and humans. In this study, we genotyped 105 S. suis isolates from porcine endocarditis in East Japan on the basis of profiles of capsular serotype-specific, virulence-associated and pilus-associated genes. The most common genotype was cps2J/mrp+/epf−/sly−/sbp2−/sep1−/sgp1+ (76.19%), followed by nt(non-typeable)/mrp+/epf−/sly−/ sbp2−/sep1−/sgp1+ (7.62%) and cps2J/mrp+/epf+/sly+/sbp2+/sep1−/sgp1− (7.62%). The representative isolates of mrp+/epf−/sly−/ sbp2−/sep1−/sgp1+ were classified into ST28 complex, a clonal complex previously referred to as ST27 complex, whereas those of mrp+/epf+/sly+/sbp2+/sep1−/sgp1− were classified into ST1 complex by multilocus sequence typing. Because the majority of human clinical isolates were assigned to ST1 and ST28 complexes, most isolates from porcine endocarditis investigated in this study may have the potential to cause S. suis infection in humans.

Chicamycin is a new antitumor antibiotic produced by a strain of Streptomyces albus, No. * This antibiotic was originally designated as BBM-2040 .

ABSTRACT. Isolates of extended-spectrum cephalosporin (ESC)-resistant Salmonella enterica serovar Typhimurium obtained from two different farms in Fukushima Prefecture, Japan, in 2007 were characterized in order to determine the genetic basis of resistance. ESC resistance in the two isolates was mediated by an AmpC β-lactamase encoded by the bla CMY-2 gene, which is located in a large selftransmissible plasmid in each isolate. The sizes of the bla CMY-2 -carrying plasmids were different. The replicon types of the plasmids were I1-I and A/C. The results of macrorestriction analysis and phage typing suggest a close relationship between both isolates. This is the first report of ESC-resistant S. Typhimurium isolated from cattle in Japan.

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