No abstract

No abstract

No abstract

No abstract

The saponin adjuvant Quil A has been investigated in the vacdnation of cattle against foot-and-mouth disease. Using a Frenkel type vaccine a dose-response relationship has been established between Quil A and neutralizing antibody tiitres. Ten ml of vaccine was combined with 0, 50, 200, 80-0, and 3200 µg of Quil A. The combinations were each injected into 4 animals. The local react•ion on the site of injection produced by injection of the vacdne alone and in combination with different doses of Quil A has been estimated. On this basis a therapeutical dose at 1 mg of Quil A has been estimated to combine maximum adjuvant effect with a minimum of adverse reactions. This dose has been tested in the vaccination of cattle with FMD vaccines derived from BHK suspension cell virus of type 0 and A resJ>ectively. The vaccines were tested in 1() ml and 5 ml doses with or without Quil A, and each in 4 alllimals. It is concluded that Quil A is a valuable adjuvant for use in the induction of neutralizing antibodies against foot-and-mouth d•isease •in cattle. adj u van t; FM D; sap on in; vaccines; neutralizing a n ti b o d i e s; Q u il A.