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This paper presents an approach based on a practical experience in applying agile and lean practices in a software development process performed into an organization evaluated CMMI level 5. As a result of a theoretical review on agile and lean practices, and the organization's needs, an integrated proposal between these practices and CMMI was found and was also put into practice. The work carried out by the organization using this proposal led to a successful integration experience in order to innovate, improve product quality, get clients' satisfaction, and the most important, show the feasibility of coexisting of CMMI and agile practices resulting in a significant improvement for the organization.