The steady state pharmacokinetics and pharmacodynamics of metoprolol controlled release tablets 100 mg CR/ZOK, was compared with those of metoprolol conventional tablets 100 mg (CT) and atenolol 50 mg (ATL) in ten healthy Oriental men. The study was of double-blind, cross-over placebo controlled design. The three study drugs and placebo were given in a random order once daily for 4 consecutive days with 1-week wash-out between each period. Treadmill exercise tests were performed and blood samples were obtained at fixed intervals after the fourth dose of each treatment. There was less fluctuation in the plasma level-time profile after CR/ZOK than CT and ATL. Plasma concentrations were significantly higher on CR/ZOK than CT at 24 hours after dosing. The relative bioavailability of CR/ZOK to CT was 69.0%. CR/ZOK achieved relatively more uniform beta-blocking effect over the dose interval. Compared to CT and ATL, the peak effect after CR/ZOK was less pronounced and the beta-blockade after 24 hours more effective.

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AbstrakTujuan Untuk menganalisis apakah bising pesawat terbang denyut nadi istirahat, dan faktor lain berperan meningkatkan risiko kejadian tekanan darah diastolik (TDD) pada penerbang TNI AU. Metode Desain penelitian nested case-control. Data berasal dari rekam medis hasil pemeriksaan kesehatan berkala dan indoktrinasi latihan aerofi siologi di LAKESPRA Saryanto di Jakarta antara Januari 2003 -September 2008. Kelompok kasus ialah subjek dengan TDD ≥90 mmHg; kelompok kontrol adalah dengan TDD ≤89 mmHg. Setiap kasus dipadankan dengan 12 kontrol. Hasil Di antara 567 penerbang, 544 (95,9%) mempunyai rekam medis yang lengkap, dan diperoleh 40 kasus dan 480 kontrol. Penerbang yang biasa terpajan bising dalam pesawat 90-95 dB dibandingkan 70-80 dB mempunyai risiko 2,7 kali menderita TDD tinggi [rasio odds (ORa) = 2,70; 95% interval kepercayaan (CI) = 1, [5][6]97]. Penerbang dengan frekuensi nadi istirahat ≥ 81/menit dibandingkan ≤ 80/minute mempunyai risiko 2,7 kali TDD tinggi (ORa = 2,66; 95% CI = 1,61). Ditinjau dari segi total jam terbang, penerbang dengan total jam terbang 1401-11125 jam dibandingkan 147-1400 jam mempuyai risiko 3,2 kali menderita TDD tinggi (ORa = 3,18; 95% CI = 1,01-10,03).Kesimpulan Intensitas bising dalam pesawat yang tinggi, frekuensi nadi istirahat yang tinggi, jumlah jam terbang total yang tinggi meningkatkan risiko TDD tinggi. Pemeriksaan mawas diri frekuensi nadi istirahat oleh penerbang dapat dipakai untuk pengendalian TDD tinggi. (Med J Indones 2009; 18: 276-82) AbstractAim To analyze the effects of aircraft noise, resting pulse rate, and other factors on the risk of high diastolic blood pressure (DBP) in Indonesian Air Force pilots.Methods A nested case-control study was conducted using data extracted from annual medical check-ups indoctrination aerophysiologic training records at the Saryanto Aviation and Aerospace Health Institute (LAKESPRA) in Jakarta from January 2003 -September 2008. For analysis of DBP: the case group with DBP ≥ 90 mmHg were compared with contral group with DBP < 79 mmHG. One case matched to 12 controls. ResultsOut of 567 pilots, 544 (95.9%) had complete medical records. For this analysis there were 40 cases of high DBP and 480 controls for DBP. Pilots exposed to aircraft noise 90-95 dB rather than 70-80 dB had a 2.7-fold increase for high DBP [adjusted odds ratio (ORa) = 2.70; 95% confi dence interval (CI ) = 1.05-6.97]. Pilots with resting pulse rates of ≥ 81/minute rather than ≤ 80/minute had a 2.7-fold increase for high DBP (ORa = 2.66; 95% CI = 1.26-5.61). In terms of total fl ight hours, pilots who had 1401-11125 hours rather than 147-1400 hours had a 3.2-fold increase for high DBP (ORa = 3.18; 95% CI = 1.01-10.03). ConclusionHigh interior aircraft noise, high total fl ight hours, and high resting pulse rate, increased risk for high DBP. Self assessment of resting pulse rate can be used to control the risk of high DBP. (Med J Indones 2009; 276: 276-82)

Latar belakang: Gagal jantung kronik merupakan penyakit progresif lambat dengan morbiditas serta mortalitas yang tinggi; penggunaan obat-obatan seringkali tidak berhasil memperbaiki hasil keluaran. Enhanced external counterpulsation (EECP) bersifat non-invasive dan merupakan alternatif terapi dalam penanganan gagal jantung. Penelitian ini bertujuan menilai pengaruh EECP terhadap myeloperoksidase (MPO) sebagai penanda inflamasi, dan pada keluaran klinis. Metode: Penelitian ini menggunakan desain uji klinik terkontrol secara randomisasi terbuka terhadap 66 penderita gagal jantung kronik pada Januari-Desember 2012. Pasien dibagi dalam dua kelompok: kelompok yang menjalani terapi EECP (n = 33) dan yang tidak menjalani terapi (non-EECP) (n = 33). Pemeriksaan MPO dilakukan pada awal dan setelah 6 bulan pengamatan. Selain itu juga dinilai kejadian kardiovaskular. Uji t tidak berpasangan digunakan untuk membandingkan kadar MPO dan uji chi-kuadrat untuk analisis kejadian kardiovaskular.

Some hypertensive subjects in Indonesia consume traditional herbal medicines in addition to the usual pharmacological drugs. This paper studied the relationship between several traditional herbal medicines, such as morinda, star fruit, garlic, or jamu, believed to control hypertension and the risk of current pharmacological antihypertensive drug users in subjects with stage 1 and 2 hypertension in a rural community West Java, Indonesia. The data were obtained from 3 field studies by the second year medical students of the