BACKGROUND: Hair is a dead tissue and is composed of keratin and related proteins. Hair is a protein offew growing cells at the base of the hair root. If the patient is diabetic glycosylation occurs in these growingcells.Since the extent of glycation of hair protein varies with the distance from the hair root, we hypothesizedthat glycation of hair protein might provide insight into blood glucose level over a period of several mouthsto one year.So hemoglobin Ale (HbAIc) may be established as an indicator of long-term blood glucosecontrol in diabetic patients. It is formed by non-enzymatic reaction of glucose with Hb.The objective of thisstudy was to estimate the furosine(an intermediate in the breaking down of amadori compounds likeglycosylated proteins) level by HPLC of glycosylated hair proteins, to find interrelation of fasting glucosewith HbAIc and furosine in diabetic patients, to determine the efficacy of Glycosylation of HbA,c andfurosinemay be a reliable marker in diabetic patients.STUDY DESIGN: This study was carried out in the department of Biochemistry Basic Medical SciencesInstitute (BMSI) Jinnah Postgraduate Medical Centre Karachi.METHODS: A total of 200 subjects were included in the study. 100 diagnosed type II and 100 controlnormal subjects. Hair from the scalp 12 cm long and 50 mg in weight was collected from each subject tomeasure furosine level. Furosine level was determined by HPLC and HbAIc, FBSand serumprotein byenzymatic kit method.RESULTS: When the mean values were compared with that of control it depicted significantly high level(0.001) of furosine, HbAIc and FBS.CONCLUSION: The furosine, HbAIc and FBS levels increases in diabetic patients while total serumprotein were unaffected. Weight and BMI increases in diabetic but height was unaffected.KEYWORDS: Diabetes mellitus type II, furosine, HbAIc, fasting blood sugar, glycation ofhair protein

Aim: To assess the relationship between body mass index and serum uric acid among healthy Pakistani adults Study design: A cross-sectional comparative study Place and Duration This study was conducted in Bakhtawar Amin Medical and Dental College Multan from November 2020 to April 2022 Methodology:A total of 250 subjects were randomly recruited out of which 120 subjects were selected in this study. Each group comprised 60 subjects. Group A comprised healthy controls subjects, while Group B comprised hyperuricemic persons with no complaints. By dividing body weight (kg) by the square of height, the BMI was computed. We divided BMI into three categories using diagnostic criteria for obesity in Asian populations given by the WHO. Participants' fasting blood samples (5 mL) were taken under stringent aseptic conditions to measure the serum uric acid level Version 23.0 of IBM-SPSS was used to store and analyse the data, Counts with percentages were reported on gender and BMI classifications between the two studied groups, and Mean with standard deviation were given for BMI and serum uric acid. Results:In the present study in group A 66.7% were male gender, 63.3% were overweight, mean BMI was 24.2 (SD=±2.0) kg/m2, and mean serum uric acid was 4.5 (SD=±0.6) units, whereas in group B there were 60% male gender, 70% were overweight, mean BMI was 23.6 (SD=±1.4) and mean serum uric acid was 8.1 (SD=±0.6) units. The independent sample test gives a significant mean difference in serum uric acid between group A and B samples with p<0.05. Conclusion: The study's findings show no significant correlation between serum uric acid, overweight and obesity among the Pakistani adult population. Keywords: Body Mass Index, serum uric acid, Pakistan, adults, overweight

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