Halofantrine has mild to moderate pathological effects on cochlea histology, and can be considered an ototoxic drug.

Background Allergy immunology specialists frequently encounter with diagnosis of migraine headache; this is a prospective study to assess the ability of the treatment of allergic rhinitis in patients having migraine to decrease the attacks of migraine. Results Between June 2016 and Feb. 2019, 58 patients suffer from migraine and having positive allergic symptoms for all patients. CBC with differential, nasal smear and IgE test assessment of migraine disability assessment score, and complete otorhinology examination were done pretreatment and 3 months post treatment score to know the effect of the treatment of allergic rhinitis on the attack of migraine. The mean age of patients was 40 years old. Age distribution was between 18 and 59 years old. Sex was also distributed and found 21 males and 37 females, showing more presented in females. Hemoglobin was found between 10.8 and 12.4 mg/dl, with mean 11.37 mg/dl; IgE test was between 5 and 800 IU/ml, with mean 171.29 IU/ml; no patients were included in grade I while the majority were included in grade III. We noticed that patients improved from allergic rhinitis and migranous attack at the same time had 43.1% while patients improved allergic rhinitis but migraine became less frequent and less sever were 15.52% (partially improved). Patients improved allergic rhinitis. Grade I no pain showed statistically significant difference, also grade III moderate pain showed statistically significant difference. IgE level in improved cases around 88.4. Conclusion There is strong relation between migraine and allergic rhinitis; the use of intranasal corticosteroid sprays and oral antihistaminic for 3 months for treatment of migraine associated with allergic rhinitis which led to decrease in the prevalence and frequency.

The aim of this work was to determine the effect of extracorporeal shock wave lithotripsy (ESWL) on the hearing of both patients and staff members exposed to such treatment. It used different hearing screening instruments, and compared the sensitivity of these instruments for the detection of the earliest change in hearing induced by this procedure. The results of this study show that ESWL has a potentially hazardous effect on hearing. This effect is subtle, could only be detected by transient evoked otoacoustic emissions (TEOAE), and is manifested in some of the subjects under study as temporary subjective hearing loss and tinnitus, reflecting a state of temporary biomechanical derangement of the outer hair cells. This effect seems to be related to the frequency of exposure to ESWL.

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