The capital structure is the ratio between long-term debt and equity capital used by the company. By using a proper comparison it will obtain an optimal capital structure. Optimal capital structure is capital structure which optimizes the balance between risk and return in order to maximize the stock price. The purpose of this study was to determine the factors that affect the company's capital structure of LQ-45 listed on the Indonesia Stock Exchange 2010-2015 period. The sampling technique used is purposive sampling method that produces as many as 13 companies. The analysis technique used is multiple linear regression. The results showed that all independent variables simultaneously affect the capital structure. T test results showed that the variable of exchange rate of US dollar against the rupiah has significant negative effect on the capital structure, the variable of tax has positive and significant impact on the capital structure, the variable of solvency has positive and significant impact on the capital structure and profitability variable has significant negative effect on the capital structure. While the variable inflation and SBI interest rate has no significant effect on the capital structure.

Failure of therapy is a result of bad adherence  medication. Non-adherence to therapy is a major factor that is suspected to result in uncontrolled blood pressure in hypertensive patients resulting in more serious complications. Therefore it is important to increase the adherence rate of treatment in patients with hypertension in the treatment process. For this reason, the need for interventions to improve  adherence  with several aspects that can be changed. This study uses One Group Pretest-Posttest Design using 100 samples. Data derived from questionnaires containing 25 items of adherence to therapy, 5 items of knowledge, 4 items of trust, 3 items of motivation, 10 items of family support with nonparametric statistical tests used were Mc Nemar test. Mc Nemar test results indicate that there is a significant difference between adherence at the pre-test and at the post-test after counseling with a significance value (p = 0,000). The results also showed that there was a difference in knowledge with a significance value (p = 0.001), motivation with a value (p = 0.031) and family support with a value (p = 0,000). The education with counseling about knowledge, trust, motivation and family support is effective in increasing compliance. There are other changeable factors such as lifestyle education, patient doctor relationships, and the use of smartphone applications for self-reported therapy can improve adherence in patients thereby minimizing therapy failure. Other educational methods that can be used besides counseling are counseling and dissemination of social media information.

Antibiotik merupakan obat yang banyak digunakan untuk mengobati infeksi, tetapi sering tidak tepat dalam pemakaiannya. Ketidaktepatan dalam menggunakan antibiotik berdampak pada resistensi. Ketidaktepatan dalam mengonsumsi dipengaruhi oleh banyak faktor, salah satunya adalah pengetahuan. Faktor pengetahuan tentang antibiotik yang baik berdampak pada ketepatan dalam menggunakan antibiotik. Kebaruan penelitian ini karena peneliti menganalisis pengetahuan dengan penggunaan antiobiotik pada masyarakat usia dewasa. Penelitian ini bertujuan untuk menganilsisis korelasi antara pengetahuan dengan penggunaan antibiotik. Penelitian ini menggunakan pendekatan cross-sectional. Populasi adalah Masyarakat Kabupaten Brebes yang berusia dewasa (18 tahun ke atas) dan dalam enam bulan terakhir pernah menggunakan antibiotik.  Besar sampel penelitian adalah  380 orang yang dipilih dengan menggunakan teknik simple random sampling. Pengumpulan data menggunakan kuesioner. Analisis data menggunakan analisis univariat dan bivariat. Uji korelasi dilakukan dengan menggunakan uji Chi-Square dengan batas signifikansi 0,05. Hasil penelitian didapatkan pemahaman tentang antibiotik mayoritas responden  pada kategori cukup baik (61,1%) dan penggunaan antibiotik paling banyak pada kategori cukup baik (51,0%). Hasil uji korelasi antar variabel pengetahuan dengan penggunaan antibiotik adalah 0,000 (pv0,005). Kesimpulan terdapat hubungan yang signifikan antara pengetahuan dengan penggunaan antibiotik. Kata kunci: Antibiotik; Pengetahuan; Penggunaan.AbstractAntibiotics are drugs that are widely used to treat infections, but are often incorrect in their use. Inaccuracy in using antibiotics has an impact on resistance. Inaccuracy in consuming is influenced by many factors, one of which is knowledge. The factor of knowledge about good antibiotics has an impact on the accuracy in using antibiotics. The novelty of this study is because researchers analyze knowledge with the use of antiobiotics in adult society. This study aims to analyze the correlation between knowledge and the use of antibiotics The size of the study sample was 380 people who were selected using a simple random sampling technique. Data collection using questionnaires. Data analysis using univariate and bivariate analysis. The correlation test was performed using the Chi-Square test with a significance limit of 0.05. The results of the study obtained an understanding of the antibiotics of the majority of respondents in the fairly good category (61.1%) and the use of antibiotics the most in the fairly good category (51.0%). The result of the correlation test between knowledge variables and the use of antibiotics was 0.000 (pv0.005). Conclusion there is a significant relationship between knowledge and the use of antibiotics.Keywords: Antibiotic; Knowledge; Usage.