Mahaparale et al.: Terbinafine Hydrochloride Polymeric MicrospongesThe objective of the present study was to develop and evaluate sustained delivery of terbinafine hydrochloride from topical polymeric microsponges. Microsponges of ethyl cellulose containing terbinafine hydrochloride were prepared by quasi emulsion solvent diffusion method. Effect of drug polymer ratio on active drug content, particle size and entrapment efficiency were studied. Drug polymer ratio greatly affects properties (entrapment efficiency, active drug content, particle size) of microsponges. Terbinafine hydrochloride microsponges showed highest actual drug content, entrapment efficiency and smaller particle size, so 1.5:1 ratio of drug and polymer was selected for optimization study. Optimization study was carried out by taking internal phase volume, stirring rate, emulsifier concentration as independent variables and their effects on entrapment efficiency, particle size were studied. It was found that as stirring speed increases, the particle size decreases and entrapment efficiency increases, while as volume of dichloromethane increases, particle size decreases. Morphology of obtained microsponges was revealed by scanning electron microscope and was found to be porous and spherical. Optimized formulation of microsponge was dispersed in Carbopol gel and evaluated for drug content, pH, viscosity and in vitro drug release. Release of drug was found to be sustained through microsponge gel as compared to marketed product and pure drug gel. Ex vivo drug deposition study was carried using rat abdominal skin. Drug deposition was found to be satisfactory. Prepared polymeric microsponges could be a potential topical drug delivery system in antifungal therapy.

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The aim of recent study was to develop a combined UV Spectrophotometric method and RP-HPLC method for metoprolol succinate, UV Spectrophotometric method was performed at 270 nm and samples were prepared with phosphate buffer solution pH 6.8, RP-HPLC method was performed using Alligent-1100 C18 column (Chemstation-32 software) at 30 0 c with flow rate of 1.0 ml/min. at detection wavelength of 215 nm. Both the methods were validated as per ICH guidelines and various validation parameters like accuracy, precision, LOD, LOQ, recovery study and range were determined. The proposed methods were simple, rapid, precise, and accurate, and can be used for routine analysis of metoprolol succinate in bulk and combinations.

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