These results, in human tissue, demonstrate that iGluR mRNA and protein expression are increased during persistent inflammation and that this increased activity may be involved in mediating clinical inflammatory pain in human skin.

Mg-based composites are fabricated through mechanical alloying (MA) the Mg65Cu20Y10Ag5 amorphous alloy spun and mixed with 1-5 vol.% spherical nano-sized ZrO2 particles in the planetary mill, after then formed by hot pressing in Ar atmosphere under different pressures at the temperature 5 K above the glass transition temperature (Tg). The microstructure characterizations of the resulting specimens are conducted by means of XRD, FEG-SEM, and TEM techniques. It is found that the nano-sized ZrO2 dispersed Mg-based composite alloy powders can reach to a homogeneous size distribution (about 80 nm) after 50-hour mechanical alloying. After hot pressing of these composite alloy powders under the pressure of 1100 MPa at 409K, a 96% dense bulk specimen can be formed. Throughout the MA and hot pressing, the amorphous nature of the Mg65Cu25Y10Ag5 matrix is maintained. The hardness of the formed bulk Mg-based composites (with 3 vol.% nano-sized ZrO2 particles) can reach to 370 in Hv scale. In addition, the toughness of the formed bulk Mg-based composites presents an increasing trend with the content of nano-sized ZrO2 particles and can reach to 8.9 MPa m .

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To extend the practical applications of bulk metallic glasses, the preparation of metallic glass coatings on various substrates becomes an important research issue. Among the interfacial properties of the coatings, the adhesion between films and substrates is the most crucial. In this study, amorphous Zr 61 Al 7?5 Ni 10 Cu 17?5 Si 4 (ZrAlNiCuSi) thin films were deposited on SUS 304 stainless steel at various sputtering powers by dc sputtering. According to the scratch tests, the introduction of Cr and Ti buffer layers effectively improves the adhesion between the amorphous thin films and substrate without changing the surface properties, such as roughness and morphology. The antimicrobial results show that the biological activities of these microbes, except Acinetobacter baumannii, are effectively suppressed during the test period.