Background: The effects of two lipidlowering drugs, simvastatin and fenofibrate on osteoporosis in the femurs of healthy and ovariectomized female rats were investigated quantitatively by histological images and

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Background: In order to counter and control the spread of the new COVID-19 pandemic, at the beginning of March 2020, the Romanian government decided to apply strict isolation and quarantine measures. Objective: In the present study, we aimed to analyze the impact of the COVID-19 pandemic and isolation/quarantine at home on lifestyle and daily diet, and to identify changes caused by the pandemic related to the nutritional status and food preferences of the Romanian population. Material and Method: We conducted a prospective observational study based on a structured questionnaire that included 30 items for investigating multiple aspects regarding the dietary habits in the context of the pandemic, quarantine and social isolation imposed by the new SARS-CoV-2 coronavirus. The questionnaire was disseminated on various online platforms accessible from any device with an internet connection in Romania, on social media groups between January and March 2021. The questionnaire was made online, using the Google Forms platform, this method being very useful for carrying out the proposed evaluation, as it facilitated the national dissemination of the evaluation questionnaire. The final study group consisted of 620 respondents from 35 counties of Romania. Results: Regarding weight status, we found that the respondents showed significantly more frequent weight fluctuations during the pandemic than before (p <0.0001). The results showed an increase in the mean weight of the respondents during the pandemic vs. their mean weight before (p = 0.04). In contrast, there were no statistically significant differences between the BMI calculated before and during the pandemic (p = 0.3). Respondents, who had a chaotic diet (40.64%) before the pandemic, became significantly more organized in this regard during the pandemic (35.96%) (p = 0.008). Conclusions: We can state that the pandemic period and isolation at home analyzed in terms of eating habits had positive consequences for about half of the study participants which adopted an organized, diversified eating behavior and balanced lifestyle.

Objectives: To evaluate the relationship between the frequency of self-declared status regarding smoking in a group of pregnant women from Mures county, Romania and the high levels of Salivary Cotinine (SC) like biomarkers. Material and methods: It was conducted a retrospective study among 230 pregnant women presented for prenatal care at 50 General Practitioners cabinets in Mures county, Romania, in 2015. Data were collected with a validated questionnaire which included age, level of education, socioeconomic status and ethnicity, also the selfreported smoking status. The Salivary Cotinine level was evaluated using NicAlert Saliva test kits. Results: Using salivary test we identified a high prevalence of involuntary exposure to cigarette smoke among both non-smokers and those who quit smoking before pregnancy. Also we registered pregnant women that although declared smoking cessation before pregnancy their salivary Cotinine levels were high, almost like to an active smoker, probably because of second-hand exposure or because they didn't say the truth about their habit. Conclusions: We underline the importance of implementing more efficient community interventions among this vulnerable group in order to reduce the frequency of smoking and sustain quitting.