No abstract

Dyslipidemia is one of the risk factors of coronary heart disease and stroke. Unripe Berlin banana flour contains chemical compounds and nutrients that may affect lipid profile. This study aimed to determine the potential effects of unripe berlin banana flour on lipid profile, especially in dyslipidemia. This experiment was conducted from July to December 2018 at the Food Analysis Laboratory of State Polytechnic of Jember and the Biomedical Laboratory of the Faculty of Dentistry, University of Jember using male wistar white rats weighed 150-200 g. The rats were then divided into a negative control group consisting of normal rats (K-), a positive control group consisting of dyslipidemia rats (K+), and a treatment group consisting of dyslipidemia rats that received 0.144 g unripe berlin banana flour (UBF). Dyslipidemia condition was achieved by administering high-fat diet (HFD) for 9 weeks. Unripe banana flour was fed to the treatment group starting from the 10th weeks for 4 weeks. The measurement of pre-intervention lipid profile was performed at 9th week while the post-intervention lipid profile was measured at 13th week. Data collected were analyzed using ANOVA. Results o showed that the Berlin unripe flour (UBF) could reduce total cholesterol and LDL levels. In addition, a decrease in HDL levels in treatment group with Berlin unripe banana flour (UBF) and in the negative control group (K-). The same decrease in HDL level was also seen in the dyslipidemia group (K+). Hence, it is concluded that Berlin banana flour has the potential to improve lipid profile in dyslipidemia rats.

Banyak Anak Berkebutuhan Khusus (ABK) mempunyai gejala hiperaktif. Gejala ini sangat mengganggu proses belajar baik di sekolah maupun di rumah. Hiperaktifitas berkaitan dengan gangguan konsentrasi dan kemampuan untuk memahami materi pelajaran. Beberapa penelitian menyebutkan bahwa ada hubungan antara makanan yang dikonsumsi ABK dengan gejala hiperaktifitas. Bahan makanan dapat mempengaruhi fungsi otak yang berkaitan dengan hiperaktifitas, pola tidur, kemampuan kognitif dan suasana hati (mood) seseorang. Berdasarkan latar belakang di atas, maka penyuluhan tentang makanan yang seharusnya diberikan untuk orang tua atau pihak yang bertanggungjawab menyediakan makanan untuk Anak Berkebutuhan Khusus (ABK) dengan tipe hiperaktif. Berkaitan dengan kondisi Pandemi Covid 19, maka penyuluhan ini dilakukan secara daring pada 98 peserta webinar yang terdiri dari orang tua ABK, orang tua non ABK, pengasuh anak, guru ABK, guru non ABK, mahasiswa jurusan kesehatan dan lain-lain. Dari hasil pos tes yang dilakukan sekitar 68% peserta bisa menjawab dengan benar pertanyaan seputar makanan yang dianjurkan untuk ABK yang hiperaktif. Semua peserta menjawab penyuluhan daring tentang nutrisi pada ABK hiperaktif ini bermanfaat.

Introduction: Thalassemia is a genetic disorder, which shows, varies phenotype due to genetic modifier. XmnI is one of the genetic modifiers which affect clinical severity in thalassemia. XmnI polymorphism may increase HbF production beyond fetal life, thus ameliorating the clinical phenotype. Aim: this study aimed to investigate the difference in HbF level and the relation of HbF level and XmnI polymorphism in Thalassemia Major (TM) and Thalassemia Intermedia (TI) patients. Methods: forty-eight beta thalassemia patients (28 males and 20 females), consists of 16 TM and 32 TI; mean age, 25.30 year old. Hemoglobin Fetal and HbA 2 level were determined using High performance Liquid Chromatography (HPLC), and XmnI polymorphism was confirmed by PCR-RFLP. Statistical analysis was done using T-test, Mann-Whitney and Pearson Chi-square. Results: The frequency of heterozygote (+/-) XmnI polymorphism in TM and TI patients was 56.25% vs 71.87%, while the frequency of homozygote (-/-) in TM and TI was 43.75% vs 28.13% with p value >0.05. The insignificant difference also found in HbF level between XmnI +/-and-/-in TM and TI patients. Conclusion: This study revealed that thalassemia major and thalassemia intermedia patients in East Java showed similar XmnI polymorphism. These phenomena also showed by HbF level in relation to XmnI polymorphism in the phenotype groups (TM and TI).

AbstrakHemoglobinopati meliputi kelainan pada struktur dan gangguan sintesis hemoglobin (thalassemia). Kelainan pada Hb ini merupakan kelainan gen tunggal yang pada awalnya ditemukan di daerah endemis malaria tetapi saat ini dapat ditemukan di seluruh dunia. Tingkat kelahiran individu homosigot atau heterosigot ganda hemoglobinopati, termasuk thalassemia alpha dan beta tidak kurang dari 2,4 per 1000 kelahiran. Anemia sel sickle menempati urutan teratas untuk kelainan pada hemoglobin. Thalassemia beta major dan HbE-thalassemia beta hampir sama banyaknya. Di Asia Tenggara dengan total penduduk lebih dari 600 juta, kelainan pada hemoglobin termasuk thalassemia, HbE dan HbCS merupakan kelainan genetik yang paling banyak ditemukan dan memiliki prevalensi tinggi. Indonesia memiliki beberapa daerah yang endemik malaria, sehingga diperkirakan banyak ditemukan kasus kelainan pada Hb termasuk thalassemia. Apabila presentase pembawa sifat thalassemia dikaitkan dengan angka kelahiran dan jumlah penduduk Indonesia, serta berdasarkan penelitian, maka diperkirakan jumlah penderita thalassemia baru yang lahir tiap tahunnya sekitar 2500 anak. Oleh karena kasus thalassemia makin meningkat dari tahun ke tahun, maka diperlukan upaya pencegahan yang dapat dimulai dengan skrining pada individu-individu yang memiliki kerabat pembawa atau penderita thalassemia. AbstractHemoglobinopathy includes structural abnormalities and haemoglobin synthesis disorders (thalassemia), is a single gene disorder that was originally found in malaria endemic areas but nowadays can be found all over the world. The birth rate of homozygous or compound heterozygous hemoglobinopathies, including alpha and beta thalassemia is less than 2.4 per 1000 births. Sickle cell anemia is the most prevalent compared to beta major and HbE-beta thalassemia. In Southeast Asia with more than 600 million people, abnormalities in hemoglobin including thalassaemia, HbE and HbCS are the most common and highly prevalent genetic disorders. Indonesia, has several areas that are endemic to malaria, there are many cases of abnormalities in Hb including thalassemia. If the percentage of carriers is associated with the birth rate and the number of Indonesian population and based on the study, it is estimated that the number of thalassemia patients born each year around 2500 children. As the case of thalassemia is increasing from year to year, it is necessary that prevention starts with screening in individuals who have relatives known as a carrier or thalassemia patient.