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Background: Therapy for chronic ulcer in diabetic patient is by modifying local inflammation response using drugs that acts as immunomodulator, neuromodulator and growth factors stimulator. Topical zinc is one of drug that can modifiy local inflammation response, immunostimulation or immunosuppresion. Purpose: This study was to prove about the number of macrophage in oral ulcer between normal and diabetes microscopically and the difference if treated by 1% ZnSO4 gel topically. Method: Ulcer in lower labial mucosa was made in normal and diabetic Wistar rats (induced by STZ), then applied 1% ZnSO4 gel and CMC-Na gel as control. They were decapitated in third and fifth day and specimen was made by processing lower labial mucosa Result: Microscopically, the result showed the number of macrophages in oral ulcer in diabetic condition was significantly higher than normal and the application of 1% ZnSO4 increased the number of macrophages in fifth day. Conclusion: The number of macrophages was higher in diabetic than normal condition, and was proven that topical application of 1% ZnSO4 increased the number macrophages of oral ulcer diabetic and normal condition.

Background: Wound healing is a complex biological process. Fibroblast is one of cell which is responsible for the wound healing process. Virgin Coconut Oil (VCO) have health benefit as antibacterial, antiinflamatory, antioxidant, and immunomodulatory. This research was purposed to know the influence use of VCO over the amount of fibroblast in wound healing after dental extraction.Method: Research quasi experimental with post test control group design and using 15 Rattus novergicus which were divided into three groups (control positive, VCO topical application, and VCO per oral application). Tooth removal was committed by using explorer, scalpel-blade, and arterial clamp. Then VCO applied everyday for 7 days. Day 7th Rattus novergicus were died, the socket after extraction were made into histological form, then the amount of fibroblast were counted with 5 field of views and made in average. Result: The number of fibroblast of the most numerous was VCO per oral ( 48,6 ± 49,8 ), VCO topical ( 36,2 ± 38,8 ), and control positive ( 33,4 ± 35,2 ). The results of the Saphiro Wilk test and Levene test acquired data normally distributed and homogeny, so it continued to One Way Anova and data showed there were significant difference among the groups of samples with value p<0,05.Conclusion: The conclusion of this research is VCO could increase the number of fibroblasts in wound healing after dental extractions

ABSTRACT

Introduction: *LQJLYLWLV LV DQ LQÀDPPDWRU\ JLQJLYD ZKLFK KDV HDUO\ VLJQ LV D little bleeding and mild swelling of the gingiva and if this gingivitis is untreated it could be the periodontitis. The process of gingivitis can be prevented with an antibacterial compound. Purpose: 7KH DLP RI WKLV UHVHDUFK LV WR GHWHUPLQH WKH HႇHFWLYHQHVV RI WRSLFDO extracts of lemongrass and clove to cure gingivitis. Methods: This experimental research used post test control group design. The samples were 28 male Wistar rats 2-3 months that were divided into 4 groups. Group I as a positive control was given amoxicillin and metronidazole, group II was given lemongrass extract, group III was given clove extracts, and the fourth group was given a combination of lemongrass and clove extracts. The addition of an extract is done in twice a day for 2 days.