A variety of voltammetric methods have been carried out for determination of brexpiprazole (BRX) using cyclic voltammetry (CV) and two different type anodic stripping methods; differential pulse (AS-DP) and square wave (AS-SWV) at modified carbon paste electrode with gold nanoparticles (AuNPs-CPEs). Additionally, electrochemical impedance spectroscopy (EIS) technique has been utilized for characterization of the different electrodes. Electrochemical oxidation behavior of BRX shows an irreversible anodic peak at 0.88 V versus Ag/AgCl, in Britton-Robinson buffer (BR) at pH 4.0, 50s preconcentration time and −0.5 deposition potential. Rectilinear relationship between the peak current versus concentration was obtained over the ranges of 1.32 × 10 −6 -6.45 × 10 −6 and 1.32 × 10 −7 -6.45 × 10 −7 mol L −1 for AS-DP and AS-SWV respectively. The lowest concentration that can be detected for both for AS-DP and AS-SWV was 3.99 × 10 −7 and 3.32 × 10 −8 mol L −1 respectively; the utilized methods have been devoted adequately for the estimation of BRX in its pure and dosage form.

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A sensitive voltammetric technique for the determination of avanafil (AVA) has been investigated at a carbon paste electrode modified with Zinc oxide nanoparticles and multi-walled carbon nanotubes (ZnO-NPs/MWCNT/CP). The study investigated the electrochemical behavior of AVA, and the morphology of the modified electrode was evaluated by transmission electron microscopy, scanning electron microscopy, and X-ray diffraction patterns. The influence of different electrodes and the content of ZnO-NPs on the voltammetric behavior of AVA were evaluated. Square wave voltammetry was studied and a linear correlation resulted within the range of (1.3-16 μg ml −1 ) with correlation coefficient 0.999, LOD 0.342 μg ml −1 and LOQ 1.141 μg ml −1 . The proposed procedure was applied successfully for the determination of AVA with good recovery in commercial dosage form and human plasma. The technique was validated and found to be accurate and reproducible according to the ICH guidelines.

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