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The present study was planned in order to investigate the effects of various oral doses of water extract of Syzygium aromaticum buds, emphases of its effect were placed on changes of the growth, serological, hematological and pathological characteristics of Wistar rats. Water extract of Syzygium aromaticum was fed to Wistar rats at 50, 200, 400 and 800 mg/kg/day for two weeks. Impairment of growth and hepatonephrotoxicity were observed in the rats of all groups. These changes were correlated with alterations in serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) activities and total protein, cholesterol and urea concentration and hematology.

The aim of this experiment is to know the toxicity of high uses of pendimethalin as herbicide used in Kenana Sugar Industry, period of experiment is 30 days. The results were reveal that there was significantly effect of high doses of pendimethalin on the liver of Wistar rats, because increase in the dose of the pendimethalin reflected by increasing the alkaline phosphatase enzyme during increase the period of time. In addition there were histopathological medical in cells of the liver of Wistar rats, which lead to impaired function of the liver, so it is very clear observed in water collected from Kenana Sugar Industry plate two, and 375 and 750 (plate three and four) compared with plate one( free from pendimethalin treatment. This experiment indicated that high dose of pendimethalin causes toxicity.