A cell-competition algorithm could be used to automatically evaluate callosal atrophy and tissue alterations. Assessments of the corpus callosal volume and tissue integrity helped to demonstrate the effects of CNS involvement in patients with SLE.

The size and shape of corpus callosum are important indicators for assisting diagnosis of many neurological diseases involving morphological changes of corpus callosum. A new automatic segmentation approach was proposed in this paper for boundary delineation of corpus callosum. The basic idea of the proposed approach was to perform segmentation on the red component of color-coded map of diffusion tensor magnetic resonance image (MR-DTI). The boundary of corpus callosum was delineated in two phases. Firstly, a rough boundary surrounding corpus callosum was derived by using a built-in contour function in Matlab. Then, this cell competition algorithm was applied to the area inside the rough boundary derived in the first phase. The proposed segmentation approach has been evaluated and compared to the Chan and Vese level set method by using the MR-DTI images of a healthy volunteer and a systemic lupus erythematorsus (SLE) patient. The implementation results showed that the proposed approach could delineate the boundaries of corpus callosum reasonably well for both cases, whereas the Chan and Vese level set method failed to catch the weak edge for the SLE patient.