BioOne Complete (complete.BioOne.org) is a full-text database of 200 subscribed and open-access titles in the biological, ecological, and environmental sciences published by nonprofit societies, associations, museums, institutions, and presses.

fThe acute response to stress consists of a series of physiological programs to promote survival by generating glucocorticoids and activating stress response genes that increase the synthesis of many chaperone proteins specific to individual organelles. In the endoplasmic reticulum (ER), short-term stress triggers activation of the unfolded protein response (UPR) module that either leads to neutralization of the initial stress or adaptation to it; chronic stress favors cell death. UPR induces expression of the transcription factor, C/EBP homology protein (CHOP), and its deletion protects against the lethal consequences of prolonged UPR. Here, we show that stress-induced CHOP expression coincides with increased metabolic activity. During stress, the ER and mitochondria come close to each other, resulting in the formation of a complex consisting of the mitochondrial translocase, translocase of outer mitochondrial membrane 22 (Tom22), steroidogenic acute regulatory protein (StAR), and 3␤-hydroxysteroid dehydrogenase type 2 (3␤HSD2) via its intermembrane space (IMS)-exposed charged unstructured loop region. Stress increased the circulation of phosphates, which elevated pregnenolone synthesis by 2-fold by increasing the stability of 3␤HSD2 and its association with the mitochondrion-associated ER membrane (MAM) and mitochondrial proteins. In summary, cytoplasmic CHOP plays a central role in coordinating the interaction of MAM proteins with the outer mitochondrial membrane translocase, Tom22, to activate metabolic activity in the IMS by enhanced phosphate circulation.

It is our opinion that archaeologists have no inherent right of access to human remains, grave goods, or objects of cultural heritage; that respecting diverse cultural views does not amount to an abdication of academic freedom; that historically archaeologists have been unanthropological in their approach to living populations and inconsistent in their treatment of indigenous peoples; and that archaeologists are fighting a losing battle when they ignore public opinion and clash with indigenous groups in the name of science. We offer some guidelines that we feel will alleviate much of the current tensions between archaeologists and indigenous peoples. A professional ethic must be devised that is consciously anthropological, values the rights of those studied and their cultural descendants in their own terms, and places academic pursuits in their proper context.

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