Background. Ki-67 is one of the new biological markers with clinical value in the pathology and prognosis of oral melanoma. It is a nuclear protein involved in regulating cell proliferation. Some studies have suggested an association between Ki-67 and poor survival in patients with oral melanoma. This systematic review was undertaken to clarify this issue. Methods. Databases of PubMed, Scopus, and Web of Science were searched using relevant English keywords from 1988 to April 2022. STATA software version 16 and random models were used for meta-analysis. Results. Eleven articles were included in this systematic review, six of which were selected for meta-analysis. The mean expression of the Ki-67 index in patients with oral melanoma was estimated at 43.81% (28.66‒58.95 with 95% CI, I2=94.2, P<0.001). In addition, the results showed a significant relationship between Ki-67 expression and the prognosis of oral melanoma lesions. Increased expression of this marker weakens the prognosis and decreases the survival rate. Conclusion. High expression of Ki-67 may serve as a predictive biomarker for poor prognosis in patients with malignant oral melanoma. Therefore, classifying this malignancy by Ki-67 expression may be considered for therapy regimen selection and integrated management.

Background Air pollution in cities has always been a permanent and serious threat for the health of society and the environment, influencing the health of different body organs and systems both acutely and chronically. Therefore, the aim of this study is to investigate the effect of air pollution in saliva Interleukin-8 (IL-8) levels in children. Materials and methods A total of 88, 8- to 10-year-old children were included in this descriptive cross-sectional study. Group I, the case group, included 44 children from Tabriz (Iranian Azerbaijan), and group II, the control group, included 44 children from Kalibar Town (of Tabriz). Both groups in this study had a similar economic status. Following sampling and selection of individuals, for measuring the levels of saliva IL-8, ELISA (enzyme-linked immunosorbent assay) method was used. To investigate the difference between the means of the groups, independent t test or its nonparametric equivalent, i.e., Man—Whitney test and Statistical Package for the Social Sciences (SPSS) 21 were used. In this study, p-value lower than 0.05 was considered statistically significant. Results The results of this study indicate a significant difference in the levels of saliva IL-8 between the two groups, where the mean level of saliva IL-8 is greater in children residing in the region with higher air pollution level than in the children dwelling in the region with a greater air pollution level (p = 0.001). Conclusion The results obtained from this study indicated that the level of saliva IL-8 increases in regions with air pollution, potentially causing several mouth problems in children. How to cite this article Mehrbani SP, Babaloo Z, Jamali Z, Abdollahian T, Eslami H, Sobhani N. Effect of Air Pollution on Salivary Interleukin-8 Levels in Children. World J Dent 2016;7(4):175-178.

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Changes in composition and flow rate of saliva depict secondary systematic variations related to diseases, drugs and treatment of illnesses. This research examines the relationship between the saliva pH and saliva resistin in the seemingly healthy individuals. In this study 82 patients referring to the Department of Oral Medicine, Faculty of Tabriz Dentistry were examined. Before sampling from the patients with inclusive conditions, their mouths were washed by water and after 15 minutes 5ml of their saliva were collected by drooling in the sterile polyethylene containers. The collected samples were transferred to the laboratory and their pH was measured. Then the enzyme-linked immunosorbent assay (ELISA) test was performed by specific kit for saliva resistin measuring. The mean value of saliva resistin was 15.60±7.56 and pH mean value was 7.61±0.68. Results showed that about 61% of patients had resistin higher than15 ng/ml. According to the analysis results, 15.9% of patients had pH less than 7 while 57.3% had pH between 7-8 and 26.8% had pH higher than 8. There was a positive relationship between saliva resistin and pH. Since salivary resistin levels vary in response to different clinical conditions, direct relationship between the saliva resistin and pH indicates that pH changes can depict risk factor for specific diseases.

Metabolic syndrome or X syndrome includes a group of metabolic and non-metabolic disorders, that increase the risk of some disease. This study aimed to determine the prevalence of metabolic syndrome in healthy subjects and patients with recurrent aphthous stomatitis (RAS) was conducted. In this cross-sectional study 33 patients with recurrent aphthous stomatitis which were referred to Department of Oral Medicine of Tabriz dental school were studied. The inclusion criteria included consent to participates in the study, lack of underlying disease associated with RAS such as Behcet’s syndrome and lack of systemic diseases. RAS patients were examined in terms of risk of the metabolic syndrome and 33 age and sex matched healthy individuals were selected and examined in terms of risk of metabolic syndrome. Data samples from check list contain demographic and laboratory findings were collected. Results showed that the prevalence of metabolic syndrome in patients with RAS (21.2%) was significantly higher than in healthy people (9.1%). (p<0.05) Female percentage of RAS patients with metabolic syndrome were 71.4 and Male percentage of RAS patients with metabolic syndrome were 28.6. Given the high prevalence of metabolic syndrome in patients with RAS, this syndrome can be considered as a risk factor for RAS.