Coronavirus disease 2019 (COVID-19) has emerged as a pandemic and public health crisis across the world. With its high infectivity and rapid spread, the severity of the disease is escalating in certain populations, especially in patients with pre-existing cardiovascular disease. In developing countries, infective endocarditis remains a problem in patients with rheumatic heart disease. We report the case of a patient with a diagnosis of infective endocarditis concomitant with COVID-19, including the diagnosis, management, and main outcomes.

This study aims to find out the difference in satisfaction level to try out competency test (UKOM) with the computer-based test and web-based test. Research method using research and development (R&D) and pre-experimental with one group pre and post-test design using purposive sampling techniques. The data were analyzed with the Wilcoxon test. This research was conducted at the Polytechnic of Health Ministry of Makassar and Megarezky Makassar University in November 2020. The results: it’s necessary to design an application for midwifery students, the design was made attractive and complete, validation results from 2 media experts averaged 87.9% and 2 material experts 94% who showed that the application is very feasible to use as well as 10 user trials with an average value of 95.1%. The satisfaction levels of tryout UKOM computer-based test by 45 users was 72.1% after given an intervention by 88.6%, so student’s satisfaction levels increased by 17,2% and the statistical test found a p-value of 0.000 < 0.05. So it can be concluded that there is a difference in the level of satisfaction of midwifery students to try out UKOM with computer-based test and web-based test.

This study aims to find out (1) the feasibility of the web-based competency test model, and (2) the effectiveness of the web-based competency test model towards increasing the confidence of midwifery students in facing the competency test. Research method using Research and Development (R &D) and Pre-Experiment One Group Pretest-Posttest with Purposive Sampling Technique which is as many as 45 samples. This research was conducted in the Polytechnic of Health Ministry of Makassar and Megarezky University in November 2020. The data is analyzed using statistical analysis by Wilcoxon Test.  Validation test results from media experts averaged 87.9% and validation results from material experts averaged 94% which showed that web competency test model applications are very feasible to use. User validation average feasibility score of 87% of the data showed that the application of web-based competency test model is very feasible to use. The results of the effective use of web-based competency test models found that the Wilcoxon Test obtained a p-value of 0.00 < 0.05. So it can be concluded that the Web-based competency test model is feasible and effective in increasing student confidence facing the competency test.

Pregnant women are a very vulnerable group to nutritional problems. The lack of knowledge, attitude, and behavior towards nutrition is the main cause of KEK (chronic energy deficiency) in pregnant women. The purpose of this study was to design an android-based application based on a needs analysis to improve nutritional knowledge and attitudes of pregnant women about KEK. The research method was qualitative research, while the design used a combined method between Research and Development (R&D) and Pre-Experiment methods with one group pre-test and post-test designs. The results of the data analysis showed that the knowledge, attitudes, and behavior of pregnant women increased by 72%, 78%, and 39%, respectively. The p-value of the McNemar test results for the variables of knowledge, attitude, and behavior was 0.000 <? (0.05), indicating there were differences in the knowledge, attitude, and behavior of pregnant women before and after using the application (p <?). It was concluded that nutrition education with Android-based application media influenced the knowledge, attitudes, and behavior of pregnant women, that is, to increase the knowledge, attitudes, and behavior of pregnant women about KEK in Meo – Meo Public Health center, Baubau City.

BACKGROUND: Periodontitis is a chronic inflammatory disease that causes damage to the supporting structures of the teeth, and if left untreated, it can lead to impaired function, appearance, pain, and tooth loss. Periodontitis is caused by bacteria that adhere to and grow on the tooth surface. The “red complex” bacteria consisted of Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia. These bacteria will trigger an inflammatory response in the body. Interleukin-6 (IL-6) is an IL that acts both as a pro-inflammatory cytokine, IL-6 is a stimulator for MMP production. To treat the periodontal disease can be through non-surgical therapy as well as surgical therapy, to maximize therapy, it is accompanied by antimicrobial therapy. However, because of the frequent use of antimicrobials, causing antimicrobial resistance in patients, the use of natural ingredients as additional therapy is very necessary for this study using Moringa leaves as a substitute for antimicrobials. AIM: This study aimed to determine the effectiveness of Moringa leaf in influencing the anti-inflammatory cytokine IL-6. The first benefit of this research is to provide scientific information in the field of dentistry regarding the effectiveness of Moringa leaves against red-complex bacteria P. gingivalis as a cause of chronic periodontitis through anti-inflammatory cytokine analysis. METHODS: The type of research that will be used is quasi-experimental with a post-test research design with a control group design. This study used a sample consisted of 30 Wistars (Rattus novergicus) and was divided into two groups based on periodontal tissue sampling as follows treatment group which was treated with extracts Moringa and control group with aquadest irrigation after bacterial induction in the gingival sulcus. Blood samples were taken on days 0, 1, 3, 5, and 7 and centrifuged obtain blood serum and serum cytokine levels (pg/mL) were quantified using a commercial ELISA IL-6 kit. RESULTS: This study obtained the results that there was a decrease in IL-6 in both groups on the 3rd day of observation (D3) where the treatment group given Moringa extract showed a greater decrease in IL-6 levels compared to the control group. There is a significant value in the comparison of IL-6 levels between the two groups with p-value: 0.000 (p < 0.05). CONCLUSION: Moringa oleifera leaf extract showed the anti-inflammatory effect on inflammation induced by the bacterium P. gingivalis. M. oleifera extract can reduce the production of the pro-inflammatory cytokine IL-6 induced by P. gingivalis bacteria in periodontitis.