In an attempt to correlate the high incidence of esophageal carcinoma in natives of certain places with their habit of using herbaceous folk medicines, we performed bioassays of several plant extracts and the fractions prepared from them. Fourteen extracts and fractions from 6 plants were injected sc into NIH Black rats. The tannin fractions from Quercus falcata pagodaefolia, Diospyros virginiana, and Camellia sinensis were very active and produced tumors at the injection site in 66% or more of the treated animals. Tannin fractions from 3 other plants and total aqueous extracts from 5 to 6 tested plants were also tumorigenic rats. The induced tumors were malignant fibrous histiocytomas similar, if not identical, to those encountered in humans. The experiment indicated a possibility of induction of tumor in man by the tested plant materials.

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Green tea is un-fermented product of Camellia for the production of green tea but C. assamica as theaflavins, tea polyphenols, epigalloctocatenin (EGCG), epicatechin (EC), epigallocatechin (EGC), gallo catechin gallate (GCG) and tea catechins. Tea possesses antimicrobial activity against Bacillus cereus, MRSA, Clostridium perfringes antioxidant, immunomodalatory and anti hypoglycemic action of tea polyphenols. Therefore, both the species of beings from various ailments.

The immunomodulatory activities of medicinal plants are well-known. Medicinal plants found natural components enhance the immune system. However, both the Camellia sinensis is found a large number of bioactive compounds that make it strong to fight against ailments. It plays a significant role in cell-mediated and humoral immunity. The immunomodulatory activity of C. sinensis was carried out by neutrophil adhesion test, antibody titer and delayed-type hypersensitivity. The present study was aimed to investigate the immunomodulatory activity of methanolic extract of Camellia sinensis in Wistar albino rats. GC–MS analysis was carried out on the potent plant (C. sinensis) to recognize bioactive volatile compounds, for their therapeutic properties, respectively. C. sinensis treated animals showed a significant outcome at dose 200 mg. GC–MS analysis was carried out of the C. sinensis to recognize bioactive volatile compounds. Out of 20, five major compounds were found are 2-Pentanone, 4-hydroxy-4-methyl, Caffeine, 1-H Benzimidazole, 2-phenyl, Hexadecenoic acid, 15-methyl, methyl ester, Trans-13-Octadecenoic acid, methyl ester. In this study, C. sinensis has more potential to modulate the immune system in experimental animals. This study provides a substantial way to replace deleterious medicines and provides natural compounds that a part of the lifestyle to get rid of diseases. The highest % area was found is 1-H Benzimidazole 2-phenyl. The pharmacokinetic property of bioactive compound was carried out by SwissADME tool.